动脉插管化疗治疗晚期舌癌.pdfVIP

金 丛 兰盘查 堡 旦筮 !鲞箜 塑 J]nterventRadiol 2008，v0J．17，No．4 · 临床研究 Clinical research· 动脉插管化疗治疗晚期舌癌 许卫国， 彭秀斌， 李鹤平， 王 于， 陈加源， 程光森 【摘要】 目的 探讨动脉插管诱导化疗在晚期舌癌治疗中的价值。方法 对2例临床分期均为Ⅲ期 的舌癌患者，由股动脉超选择插管至舌动脉注入顺铂 150—200 mg，5．FU 1．5 2．0 g以及平阳霉素50 8Omg及数支明胶海绵条，14 d后再施行舌颈联合根治术。结果 栓塞化疗 1周后肿瘤缩小，局部出现坏 死、崩解或液化，无全身性不良反应，术后1年半随访，未发现肿瘤复发或转移。结论 对中晚期舌癌患者 术前进行选择性动脉栓塞化疗疗效好，不良反应少，值得推广。 【关键词】动脉插管；舌癌；晚期；化疗栓塞 中图分类号：R815 文献标识码：A 文章编号：1008．794X(2008)．04．0284．03 Superselective arterial chemoembolizafion in treating advanced tongue cancinoma XU Wei-guo，PENG Xiu—bin，L1 lie-ping，WANG Yu，CHEN Jia-yuan，CHENG Guang-sen． Department ofRadiology，Zhuhai Peoples Hospital，ThirdAffiliatedHospitalofJinan University，Zhuhai 519000，China 【Abstract】 Objective To evaluate the inducing chemotherapy through superselective arterial approch for patients with advanced tongue squamous cancinoma． Methods Two patients with advanced tongue cancinoma ofⅢ stage were treated with lingual arterial superselective chemoembolization via femoral arterial approach with mixture of CDDP 150—200 mg，5一FU 1．5—2．0 g， PYM 50—80 mg together with stripes of gelfoam sponge．Effects of the chemotherapy were evaluated and the tumors were undergone surgery 14 d after the chemoembolization．Results The tumor masses became smaller associated with necrosis， disaggregation and liquefaction with a week after the therapy accompanied by slight systemic side effects， and signs of recurrence or metastasis Was not found after follow—up of 1 8 months．Conclusion Pre—operative superselective arterial chemoembolization would minimize complications， promote the effectiveness and be a good therapy for advanced tongue cancinoma．(J Intervent Radiol，2008，17：284—286) 【Key words】Arterial catheterization；Advanced tongue cancinoma；Chemoembolization 舌癌是口腔癌中最常见的恶性肿瘤之一，发病 57岁，病理检查均为鳞状细胞癌，1例为低分化鳞