p53 参与代谢调控的研究进展 - 生物技术通报.pdf

生物技术通报 ·综述与专论· BIOTECHNOLOGY BULLETIN ( ) 2016, 32 11 :52-58 p53 参与代谢调控的研究进展 1 2 1 1 陈珂  丁艳平  王建林  邵宝平 （1. 兰州大学生命科学学院，兰州 730000 ；2. 西北师范大学生命科学学院，兰州 730070） 摘 要 ： p53 作为肿瘤抑制因子，其不仅参与遗传毒性应激调节，而且在代谢平衡调控中也发挥重要作用。当机体或细胞处 于不同生理逆境时，活化的p53 通过参与糖代谢、脂肪酸代谢、ROS 水平等相关调节信号通路影响各种代谢途径，进而通过诱导 细胞周期阻滞、修复、衰老或凋亡的发生，最终调控机体或细胞产生代谢应激。总结了近年来p53 途径的相关报道，对p53 与癌症、 代谢综合证的关系进行了阐述，以期为进一步理解p53 参与的代谢调控提供参考。 关键词 ： p53 ；代谢应激 ；能量代谢；代谢调控 DOI ：10.13560/j.cnki.biotech.bull.1985.2016.11.007 - Research Progress on p53 involved Metabolic Regulation 1 2 1 1 CHEN Ke DING Yan-ping WANG Jian-lin SHAO Bao-ping （1. School of Life Sciences ，Lanzhou University ，Lanzhou 730000 ；2. School of Life Sciences ，Northwest Normal University ， Lanzhou 730070 ） Abstract: As a tumor suppressor，p53 not only is involved in the stress regulation of genetic toxicity，but also plays an important role in the regulation of metabolic balance. When the cells are in different physiological stresses，the activated p53 will affect various metabolic pathways by participating in the regulations of glucose metabolism，fatty acid metabolism，and ROS level. Consequently，the metabolic stress was generated by firstly inducing the occurrence of cell cycle arrest，repair，senescence or apoptosis and finally regulating the organisms and cells. This review summarized the current advances of p53 pathxxray, and discussed the role that p53 played in cancer and metabolic syndrome, which might benef