右美托咪定用于小婴儿行放射学检查补救镇静的疗效及安全性评估 卞 .docVIP

右美托咪定用于小婴儿行放射学检查补救镇静的疗效及安全性评估 卞勇 卢伊 金立红 张马忠 黄延辉 【摘要】目的方法1(g/kg右美托滴鼻起效时间、苏醒时间及总镇静时间1(g/kg右美托滴鼻关键词e efficacy and safety of rescue sedation of intranasal dexmedetomidine vs traditional rescue techniques for radiological scans in infants less than 12 months Bian Yong, Lu Yi, Jin Lihong, Zhang Mazhong, Huang Yanhui. Department of Anesthesiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China Corresponding Author: Huang Yanhui, email: paulhyh2000@ 【Abstract】Objective purpose of this study is to evaluate the efficacy and safety of intranasal dexmedetomidine compared with traditional rescue techniques for rescue sedation during radiological scans in infants less than 12 months Methods On an intention to treat protocol, of this prospective single-blinded randomized clinical trial, a total 300 children who were not adequately sedated after initial oral dose of 50 mg/kg chloral hydrate were randomly divided into three groups. Group A received intramuscular Phenobarbital of 5mg/kg. Group B received second oral dose chloral hydrate 25 mg/kg. Group C received intranasal dexmedetomidine 1(g/kg. The efficacy and safety of sedative regimens were evaluated based on the sedation onset time, wake-up time, total sedation time and clinical side-effects. The hemodynamic changes of oxygen saturation and heart rate were recorded. Results The success rate of rescue sedation among three groups was 83%, 79% and 90% and the incidence of side-effects were 7%, 12% and 8% separately with no significantly differences (P ≥ 0.05). The sedation induced time, wake-up time and the total sedation time in group C were 8(7)min, 67.5(40)min, 115(40)min respectively which had statistically differences with group A and group B. There were no significant differences in hemodynamic changes among three groups. HR decreased significantly with time among groups. And oxygen saturation of three groups was improved. Conclusions Intranasal dexmedetomidine c