sumo化对daxx亚细胞定位与功能的影响 - 生理学报.pdf

生理学报Acta Physiologica Sinica , February 25, 2013, 65(1): 89–95 89 综 述 SUMO化对DAXX亚细胞定位与功能的影响 1 1 1,2,* 2 李玲 ，文娟 ，庹勤慧 ，廖端芳 1 421001 2 410208 南华大学药物药理研究所，衡阳 ；湖南中医药大学药学院，长沙 (death domain-associated protein, DAXX) 摘 要：死亡结构域相关蛋白 是一个多功能的核蛋白，广泛分布于核仁、核质、染色 质、早幼粒细胞白血病蛋白核体(PML-NBs)和胞浆等亚细胞区域，对细胞的转录调控、凋亡及细胞周期等生物学活动发挥重 要作用。SUMO化修饰(small ubiquitin-like modification)是一种重要的、高度保守的翻译后生物学修饰，大量文献显示SUMO 化修饰对DAXX 的亚细胞定位及功能的调节具有重要意义。本文对此方面的研究进展做一综述。 关键词：小泛素相关修饰蛋白；死亡结构域相关蛋白；亚细胞定位；小泛素化 中图分类号：R363 Effects of SUMOylation on the subcellular localization and function of DAXX 1 1 1,2,* 2 LI Ling , WEN Juan , TUO Qin-Hui , LIAO Duan-Fang 1Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; 2School of Pharmacy, Hunan Uni- versity of Chinese Medicine, Changsha 410208, China Abstract: Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOy- lation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX. Key words: small ubiquitin-like modifier; death domain-associated protein; subcellular localization; SUMOylation 1997 年，Yang 等[1] 在利用酵母双杂交系统 细胞周期等方面发挥着重要作用。最新的多项 Hela Fas