肝癌家族聚集性发病的分子遗传学研究进展 - 中国细胞生物学学报.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(7): 994–997 DOI: 10.11844/cjcb.2014.07.0392 综 述 肝癌家族聚集性发病的分子遗传学研究进展 1,2 3 2 2* 张存圳 程玉强 郭卫星 程树群 1 2 3 ( 苏州大学研究生院, 苏州 215006; 第二军医大学东方肝胆外科医院, 上海 200438; 解放军234医院, 朝阳 122000) 报 摘要 许多研究表明, 肝癌(hepatocellular carcinoma, HCC)呈家族聚集性发病的倾向比较明 显, 肝癌家族史阳性的人群罹患肝癌的风险远超阴性人群。但关于肝癌聚集性发病的机制并未得 到全面的阐释。该文对近几年来与肝癌家族聚集性发病相关的研究作出综述, 以期为肝癌家族聚 集性发病的研究提供一定的理论依据。 学 关键词 肝癌; 家族聚集性; 分子遗传 Advances in Familial Aggregation of Hepatocellular Carcinoma in Molecular Genetics 学 1,2 3 2 2 * Zhang Cunzhen , Cheng Yuqiang , Guo Weixing , Cheng Shuqun 1 2 ( Graduate College, Soochow Uiversity, Suzhou 215006, China; Eastern Hepatobiliary Surgery Hospital, 3 Second Military Medical University, Shanghai 200438, China; 234th Hospital of PLA, Chaoyang 122000, China) 物 Abstract Many studies have shown that the incidence of cancer and heredity are closely related. For hepatocel- lular carcinoma (HCC), the incidence of familial aggregation tendency is also obvious, and studies have shown that the people having a positive family history of HCC suffered from HCC far more than the chance of the negative ones, but the 生 mech