泛素连接酶pirh2与恶性肿瘤相关性的研究进展 - tumor.pdf

肿瘤2011 年4 月第31 卷第4 期　Tumor Vol. 31, April, 2011　　 369 DOI:10.3781/j .issn.1000-7431.2011.04.017 Review ·综述 泛素连接酶Pirh2与恶性肿瘤相关性的研究进展 邱艳艳，董兰兰，朱果果，刘永娟，何小华，刘万红 武汉大学基础医学院，武汉　430071 [摘要]　泛素连接酶Pirh2 （p53-induced RING-H2 protein ）是一种具有E3 连接酶活性的新蛋白，能促进p53 发 生泛素化而降解，从而使p53 抑制肿瘤生长的功能减弱或消失，导致肿瘤发生和进一步恶化。近年来研究发现， 多种恶性肿瘤中Pirh2 蛋白的表达量有明显变化，这提示Pirh2 在恶性肿瘤的发生、发展中可能具有重要的作用； Pirh2 可能作为一个癌基因，在肿瘤发生过程中调节一些信号转导通路。因此，推测Pirh2 可作为肿瘤基因治疗的 一个潜在靶点。本文就Pirh2 与恶性肿瘤相关性的最新研究进展作一简要综述。 [关键词]　肿瘤形成过程；泛素蛋白连接酶类；肿瘤抑制蛋白质p53 ；Pirh2 [中图分类号]　R730.2 [文献标志码] A [文章编号]  1000-743 1(20 11)04-0369-05 Research progress in association between the ubiquitin ligase Pirh2 and malignant tumors QIU Yan-yan, DONG Lan-lan, ZHU Guo-guo, LIU Yong-juan, HE Xiao-hua, LIU Wan-hong School of Medicine, Wuhan University, Wuhan 430071, China [A BSTRACT]　Pirh2 (p53-induced RING-H2 protein), a recently identified novel protein with the intrinsic activity of ubiquitin-protein E3 ligase, can promote p53 ubiquitination and degradation. Pirh2 can repress p53-dependent tumor growth inhibition, resulting in tumorigenesis and further deterioration. Researchers have found that the expression level of Pirh2 was significantly changed in many cancers, which suggests Pirh2 is probably closely correlated with the tumorigenesis and cancer development. Otherwise, Pirh2 may act as an oncogene, which is involved in some signal pathways in tumor growth. The evidence support the potential role of Pirh2 as a promising target for cancer therapy. This review introduces the recent research progress in the correlation between Pirh2 and malignant tumors. [KEY WORDS] Neoplastic processes; Ubiquitin-protein ligases; Tumor suppressor p53; Pirh2 [Tumor,2011,31(4):369-373] 目前，随着恶性肿瘤的发生率逐渐增加，其发生、 调控p53 蛋