椭圆偏振术在生物医学研究中的应用.pdf

6 3 生命科学研究 Vol. 6 No. 3 2002 9 Life Science Research Sep. 2002 1 2 邵 方, 黄宗卿 ( 1. , 400038; 2. , 400044) :椭圆偏振术是一种新兴的用于研究生物分子固相表面 附以及 附分子间相互作用的表面分析技术. 其最大优点在于测量过程不破坏被测体系;而且灵敏度高, 可反映接近原子尺寸的变化; 又能原位实时跟踪检 测表面膜的变化情况.就椭偏术在生物医学研究的若干重要应用进行综述. :椭圆偏振术; 生物医学;应用 : 436.3;R318.51 :A : 1007-7847(2002) 03-0194-04 Application of Ellipsometry in the Investigations of Biomedicine 1 2 SHA Fang ,HUANG Zhong-qing ( 1.Dep artment of Chemistry , Third Military Medical Univ ersity , Chongqing 400038, China ; 2.Dep artment of App lied Chemistry , Ching qing Univ ersity , Chong qing 400044, China) Abstract :Ellipsometry, an optical surface-sensitive analytical technique for the investigations of bimolecular adsorp- tion reflecting solid surfaces and interactions of them at the solidliquid interfaces,has the advantages of high sensi- tivity to thepresenceof very thin surface layers,to changes in surface topography at an atomic scale.Bearing advan- tages of neither disturbing measured systems,nor involving any labeling of reactants,it can be used in real-timemon- itoring of the changes of surface film in situ.The main aspects of ellipsometric applications in the investigations of biomedicine are summarized. Key words: ellipsometry;biomedicine;application ( Lfi e Science Research ,2002,6(3) : 194~ 197) (Ellipsometry) . : , , . , ( ) , .