系统生物学软件（王栋）2010_expander.pdfVIP

protocol Expander: from expression microarrays to networks and functions 1, 5 1 1 2 1 3 4 Igor Ulitsky , Adi Maron-Katz , Seagull Shavit , Dorit Sagir , Chaim Linhart , Ran Elkon , Amos Tanay , 1 2 1 Roded Sharan , Yosef Shiloh Ron Shamir 1 2 Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, 3 4 Tel Aviv, Israel. Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Faculty of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot, Israel. 5Current address: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. Correspondence should be addressed to R.S. (rshamir@post.tau.ac.il). s l o Published online 28 January 2010; doi:10.1038/nprot.2009.230 c o t o r a major challenge in the analysis of gene expression microarray data is to extract meaningful biological knowledge out of the huge p e volume of raw data. expander (eXpression analyzer and Displayer) is an integrated software platform for the analysis of gene r u t expression data, which is freely available for academic use. It is designed to support all the stages of microarray data analysis, a n / from raw data normalization to inference of transcriptional regulatory networks. the microarray