二苯乙烯苷对胆碱能损伤拟老年性痴呆大鼠学习记忆功能和兴奋性的影响_叶翠飞.pdf

2003 9 10 Chi J Rehabil T heory Practice, October 2003, Vol 9, No. 10 593 * 叶翠飞 张兰 李斌 艾厚喜 李雅莉 张丽 李林 [ ] ( 2, 3, 5, 4D- , TSG) , ( 12mg/ kg) TSG ( 003g/ kg) (006g/ kg) ( 012/ kg) 6 , 1 , Morris T SG Morris ( P 0. 05) ; T SG3 ( P 0.01) , TSG TSG , TSG , [ ] ; ; ; ; Eff ects of 2, 3, 5, 4-tetrahydroxystilbene-2- O--D- glucoside, on learning and memory f unction and excitability in Alzheimer s disease rat induced by model cholinergic damage YE Cui-f ei, ZHA N G L an, LI Bin, et al. Dep artment of Pharmacolog , X uan- Wu H osp ital of Cap ital Universit of M edical Sciences, Beij ing 100053, China [Abstract Objective To i vestigate effects of 2, 3, 5, 4-tetrahydroxystilbe e-2-O--D-glucoside ( TSG) , o lear i g a d memory fu ctio a d excitability i Alzheimers disease rat model i duced by choli ergic damage.Methods Basal forebrai of rats w ere i jured by i- bote ic acid i jectio of 10g each side. Rats were divided i to six groups as the operatio , model, positive co trol drug do epezil hy- drochloride, TSG low ( 0. 03g/ kg) , middle ( 0. 06g/ kg) a d high (0. 12g/ kg) dose groups. These drugs were i tragastrically admi istrated for 1 mo t h The lear i g a d memory fu ctio w ere determi ed w ith Morris w ater maze, cha el w ater maze a d step through tests, a d t he excitability was evaluated by ope field a alysis Results TSG ( low, middle a d high dose) sig ifica tly decreased the sw immi g time a d error times ( P 005) i w ater maze test a d TSG high dose improved the abilit y of passive avoida ce respo se at step through test Ope field test show ed that there w as o sig ifica t differe ce o excitability betwee each groupConclusion TSG ca improve lear i g a d memory abilities of Alzheimers disease rat i duced by