软胶囊囊材的配比与胶皮溶解速率关系的研究_乔雷.pdfVIP

284 　解放军药学学报　 23 4 　　　　　　　　　　　　　 :1008-9926 (2007)04-0284-03　　:R 943　　　:A ①② 乔　雷 , 王剑波, 王四旺 ① ② ( 　　　 　7100 32, 　　　7 12046) 　:　。　, , 。　 ∶ 1. 6 ∶1, ∶0. 928 3 ∶1(k=5. 705 9)。　, 、、。 :, , , A Study of theRelationshipBetweenSoft-gelatinCapsulesShellMaterial inDi-f ferentProportionsandDissolutionRate ofCapsule Shells ①② Q IAO Lei ,WANG Jian-Bo,WANG S-iW ang ① ( Ins i u e o f M a e ria M edica, Deparm en of Pha rm acy, Four h M ili ary M edica l Un iversiy, X i’ an　710032, Shaanx i　C hina) ② ( Deparm en of Pharm acy, Shaanx i Universi y o f C hinese M edic ine, X ianyang　712046, Shaanx i　C hina) ABSTRACT:Ami To s udy he rela ionship be ween variou s ra ios and he disso lu ion ra es of he sof-ge la in cap- su le she ll befo re se lec ing he op mi um ra io. MethodsThe disso lu ion ra es o f variou s so f-ge la in cap su le shells w i h ar razine as he indica or we re de erm ind and he op mi um ra io of so f-ge la in cap su le she llw as selec ed by e- ven expermi en design. ResultsW hen he ra io o f w a er o ge la in w as 1. 6 ∶1;he ra io of g lyce ro l o gela in w as 0. 928 3 ∶1(k=5. 705 9 ), he cap sule she ll had he highes d isso lu ion ra es. ConclusionA s udy of va riou s fac ors he lp s se lec he op mi um ra io o f he sof-ge la in capsule she l.l Th is m e hod is smi ple, nove l and prac ica.l KEY ORDS:So f-ge la in cap su les;Cap su le shell;D isso lu ion ra e;Even expermi en design 　　, 、、 );250IH ( , );N-N 1 ( ,、、 );AT7 SMA RT SOTAX ,, ()。 、。, 1. 2　　(, ); , (, )( ∶、 ∶, , );( ,, ,)。 , , 2　 。、