果蝇神经干细胞不对称分裂研究进展 - 中国细胞生物学学报.PDF

网络出版时间：2013-07-23 16:17 网络出版地址：/kcms/detail/31.2035.Q1617.001.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(8): http ://www.cj DOI: 10.11844/cj cb.2013.08.0067 果蝇神经干细胞不对称分裂研究进展 周 秀 杨小杭* (浙江大学生命科学学院遗传所, 神经干细胞与发育生物学实验室, 杭州310058) 摘要 干细胞最大的特点是既能自我更新维持自身的数量, 又能分化产生不同类型的细胞 后代以构建正常的组织器官。干细胞通过不对称有丝分裂实现这种性能。不对称分裂使其中一个 子细胞继承干细胞特性, 另一个子细胞则分化产生特定类型的细胞。果蝇神经干细胞是研究不对 称分裂机制的理想系统。这篇综述主要阐述近年来在果蝇神经干细胞不对称分裂机制研究中所取 得的一些突破性进展, 并且讨论了不对称分裂缺陷与肿瘤发生之间的关系。 关键词 果蝇神经干细胞; 不对称分裂; 细胞周期; 中心体; 肿瘤发生 Mechanisms of Asymmetric Cell Division in Drosophila Neuroblasts Zhou Xiu, Yang Xiaohang* (Development and Neurobiology Lab, Institute of Genetic, College of Life Sciences, Zhejiang University, Hangzhou 310058, China) Abstract The most notable characteristics of stem cells are self-renewal and differentiation into multiple cell types. To achieve this balance, stem cells have the potential to divide asymmetrically. After asymmetric division, one daughter cell maintains stem cell identity but the other one is able to differentiate into specific cell type. Drosophila neuroblast is an ideal system to study stem cell asymmetric division. In this review, we mainly focus on the breakthrough of Drosophila neuroblasts asymmetric division mechanism in recent years, and discuss the connection between the defective in asymmetric division and tumorigenesis. Key words Drosophila neuroblast; asymmetric division; cell cycle; centrosome; tumorigenesis [3-4] [5] 1 前言