不同剂量黄芪对糖尿病大鼠认知功能影响机制的研究.pdf

结果： 1.血糖变化 治疗后，黄芪各剂量组血糖逐渐下降，同糖尿病对照组和西药组比 较，差异显著（均 P0.01）。 2.血清 SOD、MDA、8-OHdG及海马组织的SOD、MDA、8-OHdG指标，造模各组与正 常组比较，未经治疗的糖尿病模型组，SOD低于其它对照组，而MDA、8-OHdG高于为 治疗组。西药对照组与模型对照组指标相似。黄芪治疗各组均有改善但以中、高剂量 改善明显。 P0.01）。 3.定位航行实验: 治疗后，各治疗组潜伏期较模型对照组明显缩短 （均 其中，黄芪中、高剂量组潜伏期接近于正常对照组，但仍有差异（均 P0.01）。 4. 空间探索实验：治疗后，各治疗组目标象限时间百分比较模型对照组明显提 高（均 P0.01）。其中，黄芪中、高剂量组同西药对照组无差异，接近于正常对照组， 但较正常对照组仍有差异（均 P0.01）。 结论：从行为学的观察结果来看，中药黄芪可以直接有效的改善糖尿病大鼠的认 知功能和记忆功能。其机理可能是由于黄芪可以降低血糖和血脂、改善胰岛素抵抗、 营养神经细胞以及改善氧化应激等多个途径来实现的。 关键词 糖尿病；黄芪；认知功能障碍；氧化应激 A STUDY OF ASTRAGALUS ON THE INFLUENCE OF COGNITIVE FUNCTION IN DIABETIC RATS Postgraduate ： JIN li Supervisor： Prof. LIU De-shan ABSTRACT Objective：To investigate the antidiabetic, antioxidant, hypolidemic and cognitive function effect of Astragalus in diabetic rats. Methods ：The wistar rats were randomly divided into six group : normal control group, diabetic group ,naofukang treated group and astragalus treated high dose group, astragalus treated moderate dose group, astragalus treated low dose group. Except for rats in normal control group, the other five group rats were injected streptozotocin (STZ) intraperitoneally to establish the diabetic model. After that, the rats were divided administered naofukang and astragalus of various doses for 12 weeks. Observed the level of blood glucose, serum lipids, content of SOD, MDA, 8-OHdG on serum and hippocampal organization and the learning and memory ability was tested by Morris water maze. Results ： 1.Compared with the diabetic group, the level of blood glucose and serum lipids decreased(P ＞0.01) 2. Compared with the dia