原创力文档- 1、本文档共7页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
n-乙酰基转移酶2及锰超氧化物歧化酶基因多态性与 - researchgate
See discussions, stats, and author profiles for this publication at: /publication
The relationship between the gene
polymorphism of drug metabolizing enzymes
NAT2, MnSOD and antituberculosis
Article in Chinese Journal of Antibiotics · January 2016
CITATIONS READS
0 10
1 author:
Xueqiong Wu
309th Hospital of the PLA
73 PUBLICATIONS 575 CITATIONS
SEE PROFILE
Some of the authors of this publication are also working on these related projects:
I does research on tuberculosis. View project
All content following this page was uploaded by Xueqiong Wu on 24 December 2016.
The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document
and are linked to publications on ResearchGate, letting you access and read them immediately.
. 70 .
1001-8689(2016)01-0070-06
N-2
*
(309 100091)
N -2(NAT2)(MnSOD)
(antituberculosis drug-induced liver injuryATDILI) PCR-DS
101()107ATDILT()NAT2MnSOD
ATDILTNAT2MnSODATDILT
39.6%(40/101)NAT2 12.2%(13/107)NAT2 NAT2
2
(OR)4.74(95%CI 2.42~9.28 χ=20.62P0.05) MnSOD47C/C
9.9%(10/101) MnSOD47C/C1.9%(2/107)MnSOD47C/COR
2
5.77(95%CI1.23~27.02χ=6.165P0.05)NAT2MnSOD4A
NAT2MnSOD47T/TT/CBNAT2MnSOD
47C/CCNAT2 MnSOD47T/TT/CD
NAT2 MnSOD47C/CAATDILT36.8%(53/144)BATDILT
66.7%(6/9)CATDILT74.5%(38/51)DATDILT100%(4/4) 31
2 2 2
(χ=3.188P0.05)(χ=21.512P0.05)(χ=4.166P0.05)
NAT2M
文档评论（0）