福莫特罗与沙美特罗及沙丁胺醇支气管扩张效应的比较.pdf

178 2005 5 23 3 J Huaihai Med May, . 2005, Vol. 23, No. 3 福莫特罗与沙美特罗及沙丁胺醇支气管扩张效应的比较 马　真, 王海澜, 周路球 　比较 受体激动剂福莫特罗, 沙美特罗和沙 丁胺醇扩张支气管 效应。　10 名轻中度哮喘患者3 天内分 2 别吸入福莫特罗( 9 g) 、沙美特罗( 50 g) 和沙 丁胺醇( 200 g) , 比较给药前及给药后各时点 1 s 用力呼气量( FEV ) 。　吸 1 入福莫特罗和沙 丁胺醇 5 min 后即引起FEV1 显著增加, 而吸入沙美特罗则需15 min 后方引起FEV 1 显著增加; 吸入福莫特罗 及沙美特罗12 h 后仍可改善FEV 1, FEV 1 改善率分别为17% 和 16% 。　福莫特罗既可作为长效 支气管扩张剂预防和治 疗哮喘发作, 又可应用于哮喘患者急性发作时迅速控制症状, 兼具沙 丁胺醇及沙美特罗 优点。 支气管哮喘; 福莫特罗; 沙美特罗; 沙 丁胺醇; 对比研究 562. 25 1008-7044( 2005) 03-0178-02 R A , , - , - . Comparison of bronchodilating eff ects of f ormoterol salmeterol and salbutamol M A Zhen W A N G H ai lan ZH OU L u q iu (L ongg ang Centr al H osp ital of S henz hen , Guang dong 518116, China) , . Abstract Obj ective To com are t he bronchodilating effect s of inhaled formoterol salmet erol and salbutamol Methods T en - . - atients w ith mild or moderate asthma underw ent a three day t rial FEV 1 at baseline and at every tim e oint after inhalation w ere recorded. Results Formoterol and salbutamol roduced significant and ra id increases in FEV 1 within 5 min after inhalation but salmet erol exerted a slow er bronchedilating action,w hich became significant 15 min after inhalation. Formoteral and salmeterol could maint ain relaxing action after 12 h, and the mean ercentage ineceases in FEV recorded w ere 17% and 16% res ectively.