凝血因子Ⅺ——抗血栓形成的新靶点.PDFVIP

临床与病理杂志 2016, 36(6) J Clin Path ol R e s 847 doi: 10.3978/j.issn.2095-6959.2016.06.023 View this article at: /10.3978/j.issn.2095-6959.2016.06.023 凝血因子Ⅺ——抗血栓形成的新靶点 1 1 2 刘惠娜 综述 邓常清 ，贺石林 审校 (1. 湖南中医药大学血管生物学实验室，长沙 410208；2. 中南大学湘雅医学院生理学系，长沙 410008) [摘　要] 近年来血栓性疾病发病率上升，严重危害人类的健康。目前临床使用的抗血栓药物存在出血的毒 副作用。大量研究表明，凝血因子Ⅺ (factor Ⅺ，F Ⅺ)基因剔除或缺陷无出血倾向，却可以抑制闭 塞性血栓形成。近年来开展的以F Ⅺ为靶点的抗血栓研究已取得了一定进展。本文就F Ⅺ作为抗血 栓药物新靶点的依据，F Ⅺ在血栓形成中的作用及其作为抗血栓药物靶点的研究进展做一综述，以 期为研究新的抗血栓药物提供思路。 [关键词] 血栓性疾病；凝血因子Ⅺ；抗血栓形成；新靶点 Coagulation factor Ⅺ: a new target for antithrombotic drug 1 1 2 LIU Huina , DENG Changqing , HE Shilin (1. Key Laboratory of Vascular Biology, Hunan University of Chinese Medicine, Changsha 410208; 2. Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410008, China) Abstract In recent years, the incidence of thrombotic diseases is increasing, which is seriously harmful to human health. Existing clinical applications of anticoagulants can cause severe bleeding complications. Recent studies indicate that F Ⅺ-deficient mice were fully protected from occlusive thrombus without severely prolonged bleeding times. The study of antithrombotic therapy by inhibiting of F Ⅺ has made remarkable progress. On the basis of F Ⅺ, a new target for antithrombotic drug, this paper reviews the effect of F Ⅺ on thrombus formation and the recent progress on F Ⅺ for antithrombotic drug, and further w