中药保留灌肠治疗糖尿病肾病的临床视察.pdfVIP

提 要 目的：探讨中药保留灌肠治疗肾虚络阻型糖尿病肾病患者的临床有效性和安全 性。方法：将60例糖尿病肾病患者随机分为治疗组（30例，中药保留灌肠组）和对 照组（30例，爱西特组），观察两组患者治疗前后临床症状与体征、中医证候的变化 情况，以及两组患者血尿素氮（BUN）、血肌酐（SCr）、24小时尿蛋白量、血脂（TC、 TG）和空腹血糖（FPG）的变化情况。结果：临床疗效总有效率治疗组为86.67%，对 照组为53.3%,治疗组优于对照组，两组比较有统计学意义（P0.05）；中医证候的疗 效比较，两组治疗后症状积分均明显降低，两组比较有统计学意义（P0.05）；两组 均显著降低患者的血肌酐和尿素氮水平，治疗组优于对照组，有统计学意义（P0.05）； 治疗组能明显降低患者的24小时尿蛋白量，与对照组比较有统计学意义（P0.05）； 两组均降低患者血脂，治疗前后有统计学意义（P0.05），对照组与治疗组比较有统 计学意义（P0.05）；两组均未明显降低患者的空腹血糖水平，两组比较无统计学意 义（P0.05）。临床试验期间未发现明显不良反应。结论：中药保留灌肠在有效改善 患者的临床症状和体征，降低患者的血肌酐、尿素氮、血脂和 24 小时尿蛋白量等方 面有较好的临床疗效，安全性好。 关键词 糖尿病肾病；中医药治疗；爱西特；保留灌肠；临床观察 Clinical study on treating the Diabetic nephropathy with Chinese herbal decoction retention enema Speciality: Clinical medicine of TCM Author: zhurongrong Tutor: Professor Zhang Juan Abstract Objective: To observe the therapeutic effect of Chinese herbal decoction retention enema on patients with Diabetic Nephropathy. Methods: 60 patients were randomly divided into the treatment group (30 cases, with Chinese herbal decoction retention enema for eight weeks) and control group (30 cases, with medicinal charcoal capsules for eight weeks). The changes of clinical symptoms and signs, the blood urea nitrogen, serum creatinine, urinary protein ,blood-lipid （TC,TG ）and fasting blood-glucose were observed before and after treatment. Results: The total effective rate in the treatment group was significantly above the control group. The rate of treatment group was 86.67%, the control was 53.3%, there were significant differences between the two groups (P0.05). The effect of TCM symptoms of two groups were significantly reduced after treatment, with significant differences between the two groups (P0.05