中药前列康复煎剂治疗前列腺增生症的临床探究.pdfVIP

提 要 目的：评价中药前列康复煎剂治疗前列腺增生症（BPH ）肾阳亏虚型的疗效，并初 步探讨其作用机制。方法：治疗组 35 例直肠给药前列康复煎剂，每日 1 次；对照组 30 例口服盐酸坦洛新缓释胶囊 0.2mg 及保列治 5mg，每日 1 次，观察 4 周。治疗前后用记 分法记录主要症状的变化并填写国际前列腺症状评分表（IPSS ），测定最大尿流率 （Qmax ）、膀胱残余尿量（RU ）、前列腺体积，前列腺液常规化验，并记录治疗过程中 的不良反应。结果：两组疾病总有效率比较差异无显著性意义（P0.05 ），治疗组治疗后 IPSS 评分、Qmax 与治疗前比较差异均有显著性意义（P0.05 ），与对照组比较均无统计 学意义（P0.05 ）；治疗组治疗后前列腺体积与治疗前比较明显缩小（P0.05 ），与对照 组比较差异有显著性意义（P0.05 ）；治疗组治疗后前列腺液WBC 计数比治疗前明显减 少，差异有显著性意义（P0.05 ），与对照组比较差异有显著性意义（P0.05 ）；两组治 疗后膀胱残余尿量均无明显变化（P0.05 ）。结论：中药前列康复煎剂灌肠治疗前列腺增 生症肾阳亏虚型可明显改善患者的排尿症状、增加尿流率、缩小前列腺体积。其机理可 能与抑制前列腺增生、降低平滑肌张力、改善前列腺炎症有关。 主题词 前列腺增生症；肾阳亏虚型；中医药疗法；前列康复煎剂；直肠给药； 临床研究 Clinical study of qianliekangfujianji for treament of prostatic hyperplasia through sausage kidney yang deficiency Specialty:Surgery of TCM Author:Li Gang Tutor:Song IingGui Abstract Objective:To study the efficacy for treament of prostatic hyperplasia(PH).Methods: 35 patients of treatment group received qianliekangfujianji(once a day) and the controls received tamsulosin(0.2mg,once a day) and proscar(5mg,once a day),which are observed for 4 weeks.IPSS,maximum urinary flow rate(Qmax), remaining urine quantity(RU) ,WBC in expressed prostatic secretion(EPS)and the volume of Prostate gland are determined before and after treament.Results: IPSS and MER were significantly improved both in treated and controled groups(P0.01).No significant difference was found between the two groups(P0.05).The volume of Prostate gland and WBC in EPS in treated group was significantly reduced in treated group (P0.05),which was more significantly reduced than that in controled group(P0.05). No significant difference was found between the two groups in remaining urine quantity (P0.05).Conclusions: Qianliekangfujianji is e