健脾调气散结方加减联合DOF方案治疗晚期胃癌的临床探究.pdfVIP

提 要 目的：“脾胃虚弱、痰气交阻”是胃癌发病的基本病机之一，本研究从健脾益气、 调畅气机出发，观察 DOF （多西他赛+奥沙利铂+CF+5-FU ）方案化疗联合健脾调气 散结方加减治疗晚期胃癌患者的疗效。方法：将临床确诊的 44 例晚期胃癌患者随机 分成两组，其中观察组（化疗联合健脾调气散结方加减）22 例，对照组（单纯化疗） 22 例，连续观察两个化疗疗程后，比较两组治疗前后肿瘤病灶大小、主要症状、体 重、生活质量卡氏评分、QOL 评分、肿瘤标志物 CEA、CA19-9、CA24-2、免疫功能、 毒副反应的出现情况。结果：健脾调气散结方加减配合化疗可较好的改善临床症状， 稳定并增加体重，提高生活质量，提高机体免疫功能，降低肿瘤标志物 CEA、CA19-9、 CA24-2 的水平，减轻毒副反应，但在减小和稳定病灶方面与单纯化疗组相比无显著 性差异，两组对肝、肾功能的损害都不明显。结论：健脾调气散结方加减配合化疗对 晚期胃癌有确切的治疗作用，值得进一步深入研究。 关键词 晚期胃癌；健脾调气散结方；健脾益气、调畅气机 Clinical Study on Advanced Gastric Cancer Treated By “jian pi tiao qi san jie fang”Combined With Chemotherapy Speciality: Clinical Research of Integrated TCM and western Medicine Author: zhang guo rong Tutor: Professor Qi Yuanfu Abstract Objective: Taste is weak, TanQi into resistance is one of the basic pathogenesis of gastric cancer, this study from enriching qi, adjustable chang, starting DOF (DOC + OXA + CF + 5-FU) scheme chemotherapy spleen adjustable gas joint estate square to add and subtract in thetreatment of treatment of advanced gastric cancer. Methods: Will clinically diagnosed 44 cases of adanced gastric carcinoma patients into two groups at random, including the observation group (the spleen adjustable gas combined chemotherapy subtract 22 cases), party control group (22 cases pure chemotherapy), continuous observation two chemotherapy regimen, compared between the two groups after tumor lesion size before and after treatment, the main symptom, body weight, life quality ratings, QOL score, concurrent tumor markers CEA, CA19-9, CA24-2, immune function, the reaction and toxicity of the appearance Results: The spleen adjustable gas with chemotherapy can subtract estate party better improved clinica