固本祛瘀,化痰调脂法治疗老年高脂血症的临床视察.pdfVIP

提 要 目的：观察固本祛瘀，化痰调脂法治疗老年高脂血症的临床疗效，并探讨其作用 机理。方法：采用随机双盲分组的方法，将符合纳入标准的60例老年高脂血症患者 分为治疗组和对照组两组，每组各30人。治疗组采用固本调脂汤加辛伐他汀10mg 治疗；对照组采用辛伐他汀20mg治疗。8周为一个疗程。治疗前后检测患者血清总 胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、载脂蛋白水平，动脉硬化指数（AI）， 血流变学指标及患者中医症候变化情况。结果：治疗组症状改善总有效率为93.33%， 显效率为53.33%，与对照组相比较有显著性差异(P0.05)；治疗组TC、LDL-C、TG、 ApoB明显降低，HDL-C、 ApoA1明显升高，与对照组无差异(P0.05）。治疗组Lp(a) 明显降低，与对照组比较有显著性差异(P0.05或0.01)。两组治疗后动脉硬化指数 （AI）与血液流变学变化治疗组均优于对照组，有显著差异（P0.05）。结论：固本 祛瘀，化痰调脂法是治疗老年高脂血症的一种有效方法，并具有改善血流动力学变化、 动脉硬化指数水平以及患者临床症状的作用。 关键词 老年高脂血症；固本祛瘀化痰调脂；临床研究 Clinical Research on Treatment of Hyperlipidemia Using the way of supporting healthy energy,eliminating stasis, alleviating phlegm and regulating lipid Speciality：Internal Medicine of Traditional Chinese Medicine Author ：Wang Zhilin Tutor：Prof. Bao Peirong Abstract Objective: to observe the clinical curative effect of treating senile hyperlipidemia in the way of supporting energy, eliminating stasis, alleviating phlegm and regulating lipid, then research on the mechanism of the method. Methods: grouping double blindly, sixty cases of senile hyperlipidemia are devided into two treatment group, 30 person each group. The treatment group was treated with healthy energy supporting soup and 10mg simvastatin, the control group was treated with 20mg simvastatin. A treatment period last for 8 weeks. Check the following index of patients before and after the treatment: triglycerides, high-density lipoprotein cholesterol (hdl-c), low density lipoprotein, apolipoprotein level, arteriosclerosis index (AI), hemorrheology index and symptom. Results: effective rate of treatment group whose symptom were improved was 93.33%, of which 53.33% significantly. Compared with the control group, the TC, LDL-