固本降浊汤治疗慢性肾功能衰竭的临床探究.pdfVIP

提 要 目的：从临床角度研究固本降浊汤治疗慢性肾功能衰竭的疗效，并探讨其作用机 理。方法：将纳入的60例脾肾气虚，湿浊瘀阻的慢性肾功能衰竭患者随机分为两组， 固本降浊汤治疗组30例，尿毒清颗粒对照组30例，两组均配合西药对症治疗，以1 月为1个疗程，连续服用2个疗程。观察两组疗效及其对患者肾功能、血浆总蛋白及 白蛋白、血常规、血浆内皮素、二氧化碳结合力、24 小时尿蛋白定量等指标的影响 及不良反应。结果：固本降浊汤能够有效改善患者的中医证候表现（P＜0.05），改善 肾功能（P＜0.05），提高二氧化碳结合力水平（P＜0.05），明显降低血浆内皮素水平 （P＜0.05），降低 24 小时尿蛋白定量（P＜0.05），升高血浆白蛋白（P＜0.05），总 有效率为 86.67％，优于对照组 70.00％（P＜0.05）。无明显毒副作用。结论：固本 降浊汤能改善症状，保护残存肾单位，提高机体免疫力，使患者生活质量得到改善， 延缓进入替代治疗的时间。是治疗慢性肾衰竭安全有效的方剂。 关键词 慢性肾功能衰竭；固本降浊汤；脾肾气虚,湿浊瘀阻；临床研究 Clinical Study on GubenJiangzhuo Decoction Treating of Chronic Renal Failure Speciality：Internal Medicine of TCM Author ：Liu Yingying Tutor：Prof.Xu Xilan Abstract Objective: From the clinical point of view GubenJiangzhuo Decoction for the Treatment of Chronic Renal Failure efficacy, and to explore its mechanism. Methods: 60 cases will be included in the spleen and kidney qi deficiency, wet muddy Stagnation of chronic renal failure patients were randomly divided into two groups, GubenJiangzhuo Decoction therapy group 30 cases and Niaoduqing particles control group 30 cases. Both the two groups were treated with western medicine,a month for a course of treatment, taking two consecutive treatment. To observe its efficacy and its impact on renal function in patients with plasma total protein and albumin, blood, plasma endothelin, carbon dioxide combining power, 24-hour urinary protein quantitative indicators such as the impact and adverse reactions.Results: GubenJiangzhuo Decoction can effectively improve Chinese medicine card of the patient(P0.05), improve renal function (P0.05), improve the carbon dioxide cohesion level (P0.05