固表清热祛风汤治疗慢性荨麻疹的临床疗效观察和其对IL-2、IL-4的影响.pdfVIP

提 要 目的：观察固表清热祛风汤治疗慢性荨麻疹临床疗效及其对患者血清中 IL-2、 IL-4水平的影响。 方法：将 60 例表虚不固型的慢性荨麻疹随机分为 2 组，治疗组：固表清热祛风 汤，内服；对照组：祛风止痒口服液，内服。观察并记录治疗前后症状的变化。采用 放射性免疫法测量治疗组患者治疗前后血清中IL-2和IL-4水平，并与健康正常人作 比较。 结果：临床观察，治疗组的疗效明显优于对照组，且复发率低，具有统计学意义 （P＜0.05）。实验室检查，治疗组治疗前 IL-2 水平明显偏低，与正常对照组比较， 差异有显著性（P＜0.05）；治疗后水平升高，与治疗前比有统计学意义（P＜0.05）， 但与正常组比较，无显著性差异（P＞0.05）。治疗前 IL-4 水平明显升高，与正常对 照组比较，差异有显著性（P＜0.05）；治疗后水平降低，与治疗前比有统计学意义（P ＜0.05），但与正常组比较，无显著性差异（P＞0.05）。 结论：固表清热祛风汤与祛风止痒口服液治疗慢性荨麻疹表虚不固证均有较好的 临床疗效，但固表清热祛风汤疗效明显优于后者，疗效确切。其作用机制可能与调节 患者血清中IL-2和IL-4水平、改善Th1和Th2失衡状态有关。 关键词 固表清热祛风汤；慢性荨麻疹；临床研究；作用机制 Clinical Curative Effect Research on Gubiao Qingre Qufeng Decoction Treating Chronic Urticaria and its Impact on IL-2、IL-4 Speciality: Dermatology,Surgery of TCM Author: Lv Ning Tutor: Professor Song Yeqiang Abstract Objective: To observe the clinical effect of Gubiao Qingre Qufeng Decoction and its effect on IL-2. IL-4.Methods: 60 patients with exterior insufficiency syndrome of chronic urticaria were divided into 2 groups, treatment groups: Gubiao Qingre Qufeng Decoction; control group: Qufeng Zhiyang oral solution. Observe and record variations in symptoms before and after treatment. Measure IL-2 and IL-4 levels by radioimmunoassay means before and after treatment in treatment group and compare with healthy group.Results: The clinical observation showed the efficacy of the treatment group was significantly better than the control group and the recurrence rate was statistically significant(P 0.05). Laboratory tests showed the levels of IL-2 of treatment group were obviously lower than healthy group before treatment, and the difference was significan