四重金钩汤对带状疱疹后神经痛的临床疗效观察和作用机理探讨.pdfVIP

提 要 目的：观察四重金钩汤治疗带状疱疹后神经痛的临床疗效，探讨四重金钩汤治疗 带状疱疹后神经痛的作用机理。方法：研究共分为两部分。临床研究将 60 例带状疱 疹后神经痛患者随机分为四重金钩汤治疗组（30例）和吲哚美辛对照组（30例），两 组患者同时给予针灸治疗，疗程4周，用视觉模拟评分法评估、观察治疗前后两组患 者疼痛程度及治疗效果；实验研究采用小鼠扭体法、小鼠热板法实验动物疼痛模型观 察四重金钩汤的镇痛作用。结果：治疗组治愈率73.33％，与对照组比较有显著性差 异（P0.05）；总有效率90.00％，与对照组比较无显著性差异（P0.05）。实验研究 显示，四重金钩汤能明显减少醋酸所致的小鼠扭体次数, 提高热板所致小鼠疼痛的痛 阈值。结论：四重金钩汤治疗带状疱疹后神经痛疗效肯定，安全性高，毒副作用小， 可明显改善患者生活质量，其作用机制与镇痛作用有关。 关键词 带状疱疹后神经痛；中药疗法；临床研究；实验研究 The Clinical Observation and Experimental Study for Treatment Postherpetic Neuralgia With SiZhongJinGou Decoction Specialty：Dermatology,Surgery of TCM Author ： Sun Shuna Tutor： Zhang Xiaojie Abstract Objective: To observe the clinical effect of SiZhongJinGou decoction for PHN and explore its mechanism of treatment. Methods: 60 cases of PHN patients were randomly divided into 2 groups, the treatment group SiZhongJinGou decoction group and the control group for Indomethacin, two groups of patients given acupuncture treatment at the same time,Course of treatment is four weeks, Using visual analog scale assessment, observation of two groups of patients with pain and treatment before and after treatment. Experimental study on the use of writhing method in mice, mouse hot plate pain model of experimental animals to observe the analgesic effect of SiZhongJinGou decoction.Result: 73.33% cure rate in treatment group, compared with the control group were significantly different(P0.05), and the total efficiency of 90.00%, compared with the control group there was no significant difference(P0.05).Animal experiments have shown that SiZhongJinGou decoction can significantly reduce in the number of writhing in mice induced by acetic acid,to increase the pain threshold in mice due to hot-plate. Conc