固冲止血汤治疗围绝经期无排卵型功血出血期的临床探究.pdfVIP

提 要 目的：观察固冲止血汤治疗气虚血瘀型围绝经期无排卵型功血的临床疗效，探讨 其止血的作用机理。 方法：将60例气虚血瘀型围绝经期无排卵型功血患者随机分为治疗组（30例， 口服固冲止血汤）和对照组（30例，口服妇良胶囊），观察治疗前后临床症状、体征 的改善情况，治疗前后子宫动脉血流动力学、血液流变学、凝血酶原时间及部分凝血 活酶时间（PT、APTT）等指标的变化。观察治疗后治疗组与对照组组间的差异性。 结果：固冲止血汤的临床疗效确切，治疗组止血疗效的总有效率为96.67% ，两 组比较差异有显著性（p0.01）；中医证候总有效率比较，差异有显著性（p0.05）； 血液流变学指标均较治疗前明显降低（p0.01）；双侧子宫动脉血流量较加快，平均 流速增加，阻力指数降低（p0.01）；PT、APTT较治疗前缩短（p0.01）。 结论：固冲止血汤对于气虚血瘀型围绝经期无排卵型功血具有良好的止血效果， 对改善临床症状具有良好的作用。其止血的作用是通过改善纤溶活性，激活凝血因子 的活性，改善血液流变学，促进子宫局部血循环等多个环节来实现的。 关键词 固冲止血汤 气虚血瘀型 围绝经期无排卵型功血 临床研究 The Clinical Study of Guchong Zhixue Decoction in treatment of peri-menopause period of anovulatory dysfunctional uterine bleeding Hemorrhage SPeciality: Gynecology of Traditiongnal Chinese Medicine Author: Wei Xianfeng Tutor:Pro.Liu Jinxing Abstract Objective：observation of Qi deficiency and blood stasis treated by Guchong Zhixue decoction clinical effect of peri-menopausal dysfunctional uterine bleeding, exploring the hemostatic mechanisms. Method ：60 patients were divided randomly into test group (30 cases treated with GCZXD)and control group(30 cases, treated with Fukang capsule), observation treatment before and after clinical symptoms, and signs of improve situation, treatment before and after uterine artery blood flow learn, and blood rheological learn, and Thrombin original time (PT, and APTT) index of changes. Observation on treatment differences between the treatment and control groups after groups. Result ：exact Guchong Zhixue decoction: a clinical curative effect, Hemostatic effect of total effective rate of 96.67% treatment group, compared the two groups differences significant (p0.01). Total effective rate of syndrome of traditional Chinese medicine, difference