固冲止血汤治疗气虚血瘀型青春期功血出血期的临床探究.pdfVIP

提 要 目的：观察固冲止血汤治疗气虚血瘀型青春期无排卵型功能失调性子宫出血(简 称功血)出血期的临床疗效及止血机理。方法：将60例气虚血瘀型青春期功血患者随 机分为治疗组（30例，口服固冲止血汤）及对照组（30例，口服参坤养血颗粒），观 察两组止血疗效；治疗前后临床症状的改善情况；治疗前后血红蛋白（HGB）、子宫内 膜厚度、血小板体积分布幅度（PDW）、平均血小板体积(MPV)、凝血酶原时间（PT）、 部分凝血活酶时间（APTT）、血清 Ca2+等指标的变化。结果：固冲止血汤止血疗效总 有效率为90.00%，中医证候疗效总有效率93.33%，均优于对照组（P0.05）；还能提 高患者血红蛋白含量（P0.05），但与对照组相比差异无显著性（P0.05）。治疗组能 明显降低患者的子宫内膜厚度，缩短PT、APTT，升高PDW、MPV,增加血清Ca2+含量， 与治疗前相比差异均有显著性（P0.05），且作用优于对照组（P0.05）。结论：固冲 止血汤对于气虚血瘀型青春期无排卵型功血出血具有良好的止血作用，其作用机理可 2+ 能是通过降低子宫内膜厚度，促进凝血止血功能，升高血清Ca 水平等多个环节来实 现的。 关键词 固冲止血汤；气虚血瘀；青春期无排卵型功能失调性子宫出血；临床研 究 The Clinical Study of Guchong Zhixue Decoction in Treating Adolescent Anovulatory Functional Bleeding with Qi Deficiency and Blood Stasis Syndrome Speciality: Gynecology of Traditional Chinese Medicine Author: Luo Yan Tutor: Prof. Liu Jinxing Abstract Objective:To observe the effect of Guchong Zhixue Decoction (GCZXD) in treating adolescent anovulatory functional bleeding (AAFB) with Qi deficiency and blood stasis syndrome. Methods: 60 patients of AAFB diagnosed Anovulatory Dysfunctional Bleeding with Qi deficiency and blood stasis were randomly divided into the treated group(30 cases, treated by GCZXD taken orally ) and the control group(30 cases,treated by Shenkun yangxue Granule taken orally ). Observe the changes of the hemostasis effect, the improvements of clinical symptoms, thickness of endometrium, hemoglobin, prothrombin time (PT), activated partial prothrombin time(APTT), the platelet volume distribution width(PDW),the mean platelet volume(MPV) and the serum Ca2+ level .Results: The total effective rate in