4种黄连生物碱的抑菌作用（The bacteriostasis of four species of alkaloids）.docVIP

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4种黄连生物碱的抑菌作用（The bacteriostasis of four species of alkaloids）.doc

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4种黄连生物碱的抑菌作用（The bacteriostasis of four species of alkaloids）

4种黄连生物碱的抑菌作用（The bacteriostasis of four species of alkaloids） Antibacterial Activity of Four Kinds of Coptis Alkaloids 【Abstract】 Objective The contents of berberine, jatrorrhizine, berberine and palmatine were four major In order to study the antibacterial properties of four kinds of alkaloids from Rhizoma Coptidis, the antibacterial properties of this experiment were Spectral and antibacterial activity were studied. Methods Four kinds of alkaloids extracted from Coptis chinensis were used as experimental Drug, using the inhibition zone test method, in the 2000 M g / raL liquid concentration on the common 19 kinds of microorganisms The drug sensitivity test was carried out and the minimum inhibitory concentration (MIC) of the susceptible bacteria was determined by the turbidimetric method Detection. Results The contents of four kinds of alkaloid components were the same, but the antibacterial activity was different. The contents of berberine Antibacterial activity of the largest, followed by berberine and baitine, the smallest drug root; four kinds of berberine alkaloids on Gram The inhibitory activity of the bacteria is greater than that of Gram-negative bacteria and yeasts; each alkaloid has resistance to Staphylococcus aureus (MR) And Staphylococcus aureus antibacterial ability is basically the same. Conclusion Four kinds of berberine alkaloids are the antibacterial active ingredients of Coptis chinensis, The same antibacterial spectrum, but the antibacterial activity is quite different; four kinds of berberine alkaloid resistance to Staphylococcus aureus resistance Has a elimination effect. 【Key words】 berberine berberine alkaloid baitan puerarin antibacterial Abstract: ObjectiveBerberine, jatrorrhizine, palmatine, and Coptisine are four leading alkaloids from Coptidis rhizome Research the characteristics of antimicrobial activity of above Alkaloids, the antimicrobial spectrums and abilities of those were Determined in this paper. MethodsSensitivities of 19 mic