复方牛胎肝提取物治疗乙型肝炎肝硬化疗效观察.docVIP

复方牛胎肝提取物治疗乙型肝炎肝硬化疗效观察　　 卢 敏，毛 华，黄纯炽，唐银丽，张能友， 席建东　　 【摘要】目的 探讨复方牛胎肝提取物治疗乙型肝炎肝硬化患者的疗效。方法 将 120 例乙型肝炎肝硬化患者随机分为治疗组 80 例和对照组 40 例。给予治疗组复方牛胎肝联合基础护肝治疗，对照组仅予以基础护肝治疗，疗程 3 个月，对比两组患者治疗前后肝功能、 肝脏硬度值(LSM)，以及 B 超检测门静脉内径、 脾脏厚度、 脾静脉宽度的变化。结果 在 3 个月治疗结束时，治疗组患者血清 TBIL 为(33.0±2.07) μmol/L、 ALT 为(36.40±5.86) U/L、LSM 为(10.78±1.15) Kpa，均较对照组显著下降[分别为(48.62±4.24) μmol/L、 (52.60±7.3) U/L、 (15.26±2.17) Kpa，P0.05];治疗组血清 ALB 水平为(35.0±1.58) g/L，较对照组明显升高[ (31±1.58)g/L，P0.05];治疗组门静脉内径为 (1.26±0.08) cm，脾脏厚度为(3.97±0.04)cm，脾静脉宽度为(0.87±0.02)cm，均较对照组显著降低[分别为(1.36±0.05) cm、 (4.20±0.10) cm、 (0.92±0.02) cm，P0.05]。结论 复方牛胎肝提取物可显著改善乙型肝炎肝硬化患者的肝功能，减轻肝纤维化程度。　　 【关键词】 肝硬化;乙型肝炎;复方牛胎肝提取物;疗效　　 DOI：10.3969/j.issn.1672-5069.2015.02.011 　　 Efficacy of compound embryonic bovine liver extract in patients with hepatitis B related liver cirrhosis Lu Min，Mao Hua，Huang Chunchi，et al. Department of Gastroenterology，Zhujiang Hospital Affiliated to Southern Medical University，Guangzhou 510282，Guangdong Province，China 　　 【Abstract】 Objective To investigate the effect of compound embryonic bovine liver extract in patients with 　　hepatitis B related liver cirrhosis. Methods One hundred and twenty patients with hepatitis B induced liver cirrhosis were randomly divided into two groups，with 80 in treatment group receiving compound embryonic bovine liver extract tablets at the base of basic liver-protecting treatment and 40 in control group receiving the basic liv-er-protecting treatment only for 3 months. Liver function tests，liver stiffness measurement (LSM) by Fibrotouch，and portal vein diameters，spleen thickness and splenic vein width before and after treatment were compared in both groups. Results At the end of 3-month treatment，serum TBIL，ALT，and LSM values in patients in treatment group were (33.0±2.07) μmol/L，(36.40±5.86) U/L，(10.78±1.15) Kpa，respectively，significantly decreased as 　　compared with those in the controls [ (48.62±4.24) μmol/L，(52.60±7.3) U/L，(15.26±2.17) Kpa，respectively，P0.05 for all]; serum ALB levels in patient