食物源ace抑制肽的生产及构效关系研究进展 - 食品科学.pdfVIP

314 2012, Vol. 33, No. 15 食品科学 ※专题论述 ACE 王灵芝，张燕玲，王元明，乔延江 * (北京中医药大学中药学院，北京 100102) 生物活性肽是蛋白质中隐藏着的可在体内发挥一定生理功能的活性肽段。目前已从食物蛋白中获得了具有 免疫调节、抑菌、抗病毒、抗肿瘤、抗血栓形成、抗高血压等功能的多肽，其中血管紧张素转化酶(ACE) 抑制 肽是研究热点之一。ACE 通过产具有升压作用的血管紧张素Ⅱ和降解扩张血管的舒缓激肽在调节血压中发挥着重要 作用。ACE 抑制肽可通过消化道水解、发酵和熟化过程、体外酶解和遗传重组方法而获得，并可作为功能因子 添加到功能食品中，相关产品已上市或研发中。本文对 ACE 抑制肽的生产及其构效关系研究进展等进行综述。 生物活性肽；血管紧张素转化酶(ACE) ；高血压 　　A Review of Angiotensin Converting Enzyme (ACE) Inhibitory Peptides Derived from Foods: Production and Quantitative Structure-Activity Relationship WANG Ling-zhi ，ZHANG Yan-ling ，WANG Yuan-ming ，QIAO Yan-jiang* ( School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China) Abstract：Bioactive peptides are peptides with physiological functions in the body, such as immunomodulatory, antimicrobial, anticancer, antivirus, antithrombotic and antihypertension functions. Currently, peptides from foods with angiotensin convert- ing enzyme (ACE) inhibitory activity are the focus of intense study. ACE plays a vital role in the regulation of blood pressure by producing potent vasoconstrictor angiotensine II, as well as by inactivating the vasodilating bradykinin. ACE inhibitory peptides have widely been produced by gastrointestinal digestion, fermentation and maturation process, enzymatic hydrolysis and genetic recombination. These inhibitory peptides may be incorporated into functional foods and several products are currently commercially available or under development. This paper presents an overview of antihypertensive peptides derived from food protein. Key words ：bioactive peptides ；angiotensin converting enzyme (ACE)；hypertension 中图分类号：Q514.3 文献标识码：A 文章编号：1002-6630(20