低分子肝素治疗不稳定性心绞痛的临床观察 - 中南大学学报（医学版）.pdfVIP

2001, 26(4) 340 BULL HUNAN MED UNIV 姜德谦, 文 丹, 周胜华 ( 中南大学湘雅二医院心内科, 长沙 410011) [ ] 对67例临床诊断为不稳定性心绞痛患者,采用单盲对照的完 随机化方法,分为低分子肝素治疗及小 剂量尿激酶溶栓治疗组通过常规心电图和动态心电图24 h 缺血总负荷及30 d 发生心梗的例数和死亡率, 比较两种 治疗方法疗效和安 性两组治疗在减少心绞痛发作和缺血总负荷方面无统计学差异, 但溶栓组发生心肌梗塞 (AMI) 2例, 发生出血5 例( 鼻衄2 例牙龈出血2 例便血 1 例) 作者认为低分子肝素治疗比小剂量尿激酶治疗有更 好的安 性 [ ] 心绞痛; 不稳定性; 肝素,低分子量; 尿激酶; 治疗应用 [ ] R5414 [] A [ ] 2001) Effect of low molecular weight heparin on unstable angina JIANG Deqian, WEN Dan, HOU Shenghua ( D epartment of Cardiology , The Second X inagya H osp ital , Central S outh University , Changsha 410011, China ) Abstract : Obj ective To evaluate the effect of low molecular weight heparin ( LMWH) and verus urokinase (UK) on unstable angian ( UA) . Methods Sixty seven patientswith UAwere divided in two groups by a single blind, controlled, randomized method: LMWH ( anti- thrombi) group andUK (thromlytic therapy) group. Total ischemia load in 24 hours ambulatory ECG, mortality and cases of acute myocardial infarction (AMI) in 30 days were employed to compare the effect and safety between two groups. Results There was no significant difference in decreasing attacks of angina pectoris and total ischemia load between two groups. The UK group had two cases of AMI and five cases of complications of bleeding (two cases of epistaxis, two cases of bleeding gums, one case of hematochezia) . Conclusion Antithrombin theraphy is prior to thromblytic therapy, treatment of LMWH is safer than that of low dose UK in UA. Key words: unstable angina; low molecular weight heparin; urokinase; therapeutic use