妇血平颗粒对瘀热兼气虚型青春期无排卵性功血出血期的临床探究.pdfVIP

提 要 目的：观察妇血平颗粒治疗瘀热兼气虚型青春期无排卵性功血出血期的临床疗效 并探讨其止血机理。方法：选择60例瘀热兼气虚型青春期无排卵性功血出血期患者， 治疗组30例（口服妇血平颗粒），对照组30例（口服致康胶囊），观察两组患者止血 疗效、临床症状、治疗前后子宫内膜厚度、血管内皮素－1含量、凝血酶原时间（PT） 及活化部分凝血活酶时间(APTT)的变化。结果：治疗组与对照组近期止血疗效总有效 率分别为：96.67％、63.33％，两者相比有显著性差异（P0.05）；中医单项症状及 治疗前后症状积分治疗组与对照组相比有显著性差异（P0.05）；治疗组在改善临床 症状，缩短凝血酶原时间（PT）及活化部分凝血活酶时间（APTT），降低血ET-1含量， 降低子宫内膜厚度方面与治疗前相比均有显著性差异(P0.05)，且与对照组治疗后比 较有显著性差异(P0.05)。结论：妇血平颗粒对瘀热兼气虚型青春期无排卵性功血出 血期止血效果明显，并能显著改善伴随症状，其机理可能与缩短凝血酶原时间及活化 部分凝血活酶时间，降低血 ET-1 含量，降低子宫内膜厚度，改善子宫局部微环境、 抗菌消炎等有关。 关键词 妇血平颗粒；瘀热兼气虚型；青春期无排卵性功血；临床研究 The Clinical Study of Fuxueping Granule in Treating Juvinile anovulatory dysfunctiona uterine bleeding With Blood Stasis and Caloric and Qi deficiency Syndromeand Speciality：Gynecology of Traditional Chinese Medicine Author ：ZhangLijun Tutor：Prof. YeQing Abstract Objective：To investigate the hemostatic effect of Fuxueping Granule in treating juvinile anovulatory dysfunctional uterine bleeding with hot blood and qi deficiency form and its mechanism. Methods ：60 cases of juvinile anovulatory dysfunctional uterine bleeding with Blood Stasis and Caloric and Qi deficiency form , were divided randomly into the treatment group (30 cases, treated with FXPG), the control group (30 case ，treated with ZKC). The hemostasis effect,the improvements of clinical symptoms and prothrombrn time(PT)and activated partial prothrombrn time(APTT), the Endometrial thickness in change. Results ：The clinical total efficiency is 96.67% in treament group,and 63.33% in control group,there is significent difference between them(P0.05) ；The improvements of clinical symptoms and symptom