莫西沙星序贯治疗社区获得性肺炎临床探究.doc

莫西沙星序贯治疗社区获得性肺炎临床探究【摘要】 目的 研究莫西沙星治疗社区获得性肺炎的临床疗效、安全性。方法 216例轻中度社区获得性肺炎患者随机分为3组。A组(观察组)予莫西沙星序贯治疗,B组(对照组)予左氧氟沙星序贯治疗,C组(对照组)予头孢曲松钠/头孢泊肟酯联合阿奇霉素常规序贯治疗。结果 ①A组、B组和C组痊愈率分别为70.3%(52/74)、67.1%(47/70)和 47.2%(34/72),临床有效率分别为86.5%(64/74)、82.9%(58/70)和72.2%(52/72),细菌清除率分别84.8%(28/33)、82.1%(23/28)和58.1%(18/31),3个指标中,A、B两组间差异均无统计学意义,A、C两组间差异均有统计学意义;②A组、B组和C组静脉注射时间分别为(2.27±1.14)d、(2.33±1.15)d和(3.03±1.08)d,A、B两组间差异无统计学意义,A、C两组间差异有统计学意义;③A组、B组和C组不良反应发生率分别为5.4%(4/74)、5.7%(4/70)和13.9%(10/72),A、B两组间差异无统计学意义,A、C两组间差异有统计学意义。结论 莫西沙星序贯治疗社区获得性肺炎效果更为确切、安全。 【关键词】莫西沙星;社区获得性肺炎;序贯治疗 The clinical research of sequential moxifloxacin therapy in patients with community acquired pneumonia WANG Ye-jian,ZHANG Xiao-ju,YU Chun-yao,et al.The Infectious disease hospital of Henan (Sixth Peoples Hospital of Zhengzhou City),Zhengzhou450000,China 【Abstract】 Objective To evaluate the efficacy and safety of sequential moxifloxacin therapy in the treatment of patients with community acquired pneumonia.Methods One hundred and sixteen patients with community acquired pneumonia were randomly divided into three groups.In group A(moxifloxacin sequential group),moxifloxacin was administered by intravenous infusion 400 mg/250 ml oncedaily until to appear “clinical standard” of intravenousinfusionturned into oral administration,followed by oral administration at the same dose.The total treatment duration was also 7~12 days.In group B(control group),levofloxacin was administered by intravenous infusion 0.2 g/250 ml twice dailyuntil to appear “clinical standard” of intravenous infusion turned into oral administration,followed by oral administration 0.1 g twice daily.The total treatment duration was also 7~12 days.In group C(control group),ceftriaxone sodiumwas administeredbyintravenousinfusion2.0 g/250 mlonce dailyuntilto appear “clinicalstandard” of intravenous infusion turned into oral administration,followed by oral administration Cefpodoxime 0.1 g twice daily with Azithromycin 0.5 g once daily.The total treatm