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Clinicopathological significance of chemotactic factor IL-8, MCP-1 and MIP-1αexpressions in gallbladder carcinoma.pdfVIP

Clinicopathological significance of chemotactic factor IL-8, MCP-1 and MIP-1αexpressions in gallbladder carcinoma.pdf

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Clinicopathological significance of chemotactic factor IL-8, MCP-1 and MIP-1αexpressions in gallbladder carcinoma

C-iniCopath0logiCaIsignificanceofchemotactic factorIL一8,MCP一1andMIP—loexpressions ingallbladderca LiangZeng,XiaoyanWang,LixueZhou。,ChaoGuo。,ChunlinCai,JinshuWu r C Department of Pathology,Hunan ProvincialTumor Hospital,The Affiliated Tumor Hospitalof Xiangya n MedicineSchoolofCentralSouthUniversity,Changsha41000,China o DepartmentofRehabilitationandDermatology,RenminHospitalofTulufan,Turpan83800,China 。DepartmentofHepatobiliarySurgery,HunanProvincialPeople’sHospital,Changsha410000,China m TheForthInfectionDepartment,TheFirstHospitalofChangsha,Changsha410011,China a Received:28June2013/Revised:20July2013/Accepted:15August2013 @HuazhongUniversityofScienceandTechnologyandSpringer-VerlagBerlinHeidelberg2013 Abstract Objective:Gallbladdercarcinomawas.oneofthemalignantIumorsjnfhedigestivesystem.characterizedby hiohrecurrenceandinvasion.RecentresearchIndicateslhatchemotacticfactorssuchaslL-8,MCP一1andMIP一1ahave playedanimportantroleinsuchaspectsasformulation,growth,shiftingoflhelumor,Theaimofthisstudywasloinvestigate expressionsofIL-8.MCP.1andMIP.1aingallbladderadenocarcinomatissues.MethoOsGallbladderadenocarcinomaand noncancerouslissueswereroutinelyformalin.fixedandparaffin—embedded.andinsituhybridizationassayforIL一8,MCP-1 andMIP.1QmRNA.Results:(1)ThepositiveratesorthescoringsoflL-8,MCP-1andMIP一1amRNAweresignificantlyhigher inhumangallbladderadenocarcinomalhanlhoseInhumanchroniccholecystitis(P0.01).Thepositiveratesorlhescorings oflhreefactorswerelowerinwel1.differentiatiatedgallbladderadenocarcinomalhaninpoorly-differenfiattedones,whereas fherewasonlyonesignificantdifferencebetweenMCP.1mRNA(PO.05).Thecloselypositivecorrelationwerefoundamong

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