男女原发性干燥综合征的临床及血清学特点分析.pdfVIP

山西医药杂志2008年3月第37卷第3期 Shanxi Meal J,March 2008,Vo1．37,No．3 ·207 · — — 男女原发性干燥综合征的临床及血清学特点分析 山西医科大学第二医院(030001) 赵文鹏 许 珂 霍月红 李小峰 【摘 要】 目的 探讨男女原发性干燥综合征(pSS)的临床及血清学特点，提高诊断治疗水平。方法 对 1 l8例确诊为pSS的患者的I临床及血清学资料进行回顾分析。结果 两性间平均发病年龄和平均病程差异无统 计学意义；男性pSS患者的121眼干燥症状发生率较低，症状较轻(P0．05)；低热、全身疲乏等一般表现显著多于 女性(P0．05)；腺外表现较女性多见，尤以肺间质纤维化发生率较高(P0．05)；男性类风湿因子(RF)阳性率 较低(P0．05)。结论 pss是慢性全身性免疫性疾病。男性患者外分泌腺症状发生率较低，一般症状及腺外受 累更为多见，RF阳性率较女性低。 【关键词】干燥综合征；性别因素； I临床表现； 自身抗体 Clinical and serological difference between male and female cases of primary sji；gren S syndrome ZHAO W 一peng， XUK ，HUO Yue-1wng，LJ Xiao-feng． P Second Hos~ml ofShanxi Medical University，Taiyuan 030001，China 【Abstract】Objective To compare the clinical and~rological difference of primary Si~,ren S syndrome in both sex to improve the level of diagnosis and treatment．Methods Clinical and serological data of I18 cAtse~of pSS were an— alyzed retrospectively，Results No significant difference was found between male and female in mean age of onset and average disease duration at the time of diagnosis．Compared with female patients．dry mouth and dry eyes were 1ess fre— quent(P0．05)．General symptoms，such as fatigue，low-grade fever，depression，hypomnesia，and SO on，were more cornlTlOn(P0．05)．The frequency of extraglandular manifestations especially pulmonary interstitial fibrosis was significantly higher in male than in female(P0．05)．The incidence of positive RF was lower than in female(P 0．05)．Conclusion Primary Sj~gren S syndrome is one of the systemic immune diseases．For male pss patient，glan— dular manifestations appeared later and milder，but general sym ptoms and extraglandular manifestations are more com— mon．The incidence o