清胰化积汤治疗湿热型慢性胰腺炎的临床探究.pdfVIP

提 要 ( ) 目的：观察清胰化积汤治疗慢性胰腺炎 chronic pancreatitis，CP ，中医辨证为湿 热型的临床疗效，并从理论和临床研究两个方面探讨清胰化积汤治疗湿热型CP 的作 用机制。方法：临床选择符合纳入标准的CP患者60例，随机分为两组，治疗组（30 例）给予清胰化积汤，对照组（30例）给予清胰利胆颗粒，两组均以4周为一疗程。 观察两组的临床疗效，并对患者随访6个月，观察远期疗效。结果：临床研究显示， 治疗组在中医证候的改善率及改善程度方面优于对照组（P ＜0.05或P ＜0.01 ）。治疗 组能明显改善脘胁痛疼、腹胀、纳呆食少等症状，其疗效优于对照组（P ＜0.05或P ＜0.01 ）。两组治疗期间均未发生不良反应。结论：清胰化积汤是治疗湿热型CP 的有 效方剂，其机理可能与改善胰腺微循环、增加胃肠动力、抗炎、利胆等有关。 ( ,CP) 关键词 清胰化积汤；慢性胰腺炎 chronic pancreatitis ；湿热证；临床研究 Clinical Study of Treating Chronic Pancreatitis of Damp-heat Syndrome with Qingyihuajitang Specialty：Gastroenterology.Internal Medicine of TCM. Author ：Sun Yangxin Tutor：Professor Lu Guangchao Abstract Objective:To observe the effect of Qingyihuajitang(QYHJT) on Prolapse of Chronic Pancreatitis (CP) and explore the mechanism of it. Methods: 60 patients with CP were divided into two groups at random:the treatment group and the control group. The treatment group was given QYHJT, and the control group was given Qingyilidankeli(QYLDKL).4 weeks were set as a course of treatment.The clinical effects of each group were observed during the course and the follow-up survey of 6 months. Results: The effective of syndrome of TCM, observing of the treatment group are better than that of the control group (P ＜0.01 or P ＜0.05). QYHJT can improve more significantly the symptoms such as abdominal pain, abdominal distention and anorexia fatigue than Qingyilidankeli (P ＜0.01 or P ＜0.05). Conclusions: QYHJT appears to have the significant effect in the treatment of CP. The mechanism of this therapy may be relation to Improve