益气通脉新加对气虚寒凝血瘀型糖尿病下肢血管病变的临床干预.pdfVIP

提 要 目的：探讨益气通脉新加汤治疗气虚寒凝血瘀型糖尿病下肢血管病变患者的临床 疗效和安全性。方法：将 60 例气虚血瘀寒凝型糖尿病下肢血管病变患者随机分为治 疗组（30例，益气通脉新加汤合并凯时组）和对照组（30例，单用凯时组），观察两 组治疗前后中医症候、踝肱比以及总胆固醇（TC）、甘油三酯（TG)、低密度脂蛋白（LDL-C) 和纤维蛋白原（FIB）的变化情况。结果：临床中医症候疗效总有效率治疗组为86.67%， 对照组为 70.00%，两组皆有显著疗效，治疗组优于对照组，两组比较有显著差异 （P0.05)；两组均显著改善踝肱比、总胆固醇、甘油三酯、低密度脂蛋白和纤维蛋 白原水平，治疗前后比较有显著差异性(P0.05),两组比较治疗组优于对照组，有显 著性差异（P0.05)。试验期间未见不良反应。结论：益气通脉新加汤在改善糖尿病 下肢血管病变患者的症状体征方面有很好疗效，能有效改善踝肱比、总胆固醇、甘油 三酯、低密度脂蛋白和纤维蛋白原的水平，且安全性高。 关键词 糖尿病下肢血管病变；益气通脉新加汤；气虚寒凝血瘀；临床干预 Clinical interventions on the Qixu Hanning Xueyu diabetes with lower extremity arterial disease by Yiqi Tongmai Xinjia Tang Speciality：Clinical medicine of TCM Author ：Li Yangyun Tutor:Associate professor Yang Wenjun Abstract Objective:To observe the clinical efficacy and safety of Yiqi Tongmai Xinjia Tang on the Qixu Hanning Xueyu diabetes with lower extremity arterial disease.Methods:60 patients were randomly divided into the treatment group (30 cases,with Chinese Medicine and Alprostadil Injection for eight weeks) and control group (30cases, with medicinal Alprostadil Injection for eight weeks).The changes of TCM symptoms, the ankle-brachial ratio and total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and fibrinogen (FIB) were observed before and after treatment. Results: The total effective rate of TCM clinical in the treatment group was 86.67%,the control is 70.0%, both groups a significant effect in the treatment group than the control group respectively,before and after treatment there were significant differences(P0.05). The two groups were significantly improved ankle-brachial ratio, total cholesterol, triglycerides, LDL and fibrinogen level, with significant differences between the two groups (P0.05).