益肺止喘膏外敷防治儿童哮喘的临床及实验研究.pdfVIP

提 要 目的：通过临床及实验研究观察益肺止喘膏防治儿童哮喘复发的疗效，并探讨其 作用机理。方法：临床观察哮喘缓解期患儿 60 例，随机分成益肺止喘膏治疗组 30 例，酮替芬对照组 30 例，观察患儿治疗前后的临床症状、体征和实验室检查结果变 化。实验研究观察益肺止喘膏对健康成年家兔皮肤刺激的影响；观察益肺止喘膏对豚 鼠的化痰、平喘作用，并分别与氯化铵及磷酸组胺比较；观察益肺止喘膏对 wistar 大鼠网状内皮系统血流中惰性炭粒的吞噬廓清能力及肠系膜微循环的影响。结果：临 床研究结果显示：治疗组总有效率为 93.33%，对照组总有效率为 73.33%，治疗组总 疗效优于对照组(P0.05)。治疗组在主要临床症状、体征，发作次数，肺功能及实验 室检查指标方面优于对照组。实验研究结果显示：益肺止喘膏外用安全；平喘，化痰 作用强；能增强大鼠网状内皮系统血流中惰性炭粒的吞噬廓清能力；使大鼠肠绊关闭 的微血管明显开通。结论：益肺止喘膏能够有效减轻气道慢性炎症，降低气道高反应 性，改善肺部微循环障碍，从而有效防治哮喘的复发。 关键词 外治法；益肺止喘膏；儿童哮喘；临床研究；实验研究 Clinicai Study and experimentail research on Prevention and Treatment of Infantile Asthma by Yifeizhichuan Plaster Stuck onto Special Acupoints Author ：XueJunMei Speciality：Respiratory Disease Pediatrics of TCM Tutor ：Professor WangMingXiang Abstract Objective：Through clinical and experimental observations Yifeizhichuan Plaster Stuck onto special acupoints relapse prevention and treatment efficacy in children with asthma and to explore its mechanism.Methods: Collecting 60 clinical patients with infantile asthma,which were randomly divided into two groups. One(30patients) treated by Yifeizhichuan Plaster was treatment group and the other treated by Ketotifen Pill was control one. Experimental study on observation of Yifeizhichuan Plaster Stuck of healthy adult rabbits the effects of skin irritation;Observation Yifei zhichuanHuatan cream on guinea pigs,anti-asthmatic effect,and separately with ammonium chloride and phosphate of histamine comparison;observation Yefei zhichuan cream of wistar rat reticuloendothelial system blood flow in the tablets of inert carbon clearance hagocytic ability and mesenteric microcirculation.Resules:The clinical study showed that the total effective rate