糖尿病肢体动脉闭塞症中医辨证分型与血流动力学和踝臂指数相关性研究.pdfVIP

提 要 目的：探讨糖尿病肢体动脉闭塞症中医辨证分型与血流动力学及踝臂指数的相关 性及相关程度，初步总结判断不同中医证型的彩超客观化标准，为糖尿病肢体动脉闭 塞症的临床辨证分型提供客观依据。方法：选取该病患者100例为研究对象，其中血 瘀证组50例，湿热证组50例，同时以健康自愿者20例作为为正常对照组。选取13 项临床相关检查指标，运用方差分析、秩和检验、Logistic回归分析等统计学方法， 初步探讨糖尿病肢体动脉闭塞症常见证型血瘀型和湿热型与股总动脉的平均血流速 度（MA）、阻力指数（RI）、脉动指数（PI）、踝臂指数（ABI）、空腹血糖（FBG）、总 胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、血栓素 B (TXB )、6-酮-前列腺素 F (6-Keto-PGF )、活化部分凝血活酶时间（APTT－S） 2 2 1α 1α 及纤维蛋白原（FIB）的相关性。结果：与正常对照组相比糖尿病肢体动脉闭塞症患 者各项检查指标均有不同程度的差异。运用 Logistic 回归分析，建立了最优回归预 测方程，筛选出与糖尿病肢体动脉闭塞症中医辨证分型关系密切的4项指标，即PI、 FBG、HDL 和 FIB。结论：PI、FBG、HDL 和 FIB 与糖尿病肢体动脉闭塞症中医辨证分 型关系密切，可作为评价糖尿病肢体动脉闭塞症中医辨证分型的客观指标参考。 关键词 糖尿病肢体动脉闭塞症；中医辨证分型；彩色超声多普勒；血流动力学； 踝臂指数 The Research on correlation of DLAO’s syndrome differentiation of TCM with hemodynamics and ankle-brachial index Speciality:Peripheral Vascular Diseases,Surgery of TCM Author:Fan Changhai Tutor:Prof.Chen Bainan Abstract Objective:To explore the correlation of DLAO’s syndrome differentiation of TCM with hemodynamics and ankle-brachial index,preliminarily summarize and judge Color ultrasound Doppler’s objectivity standard of the different TCM syndrome type,and provide the objective evidence for DLAO’s clinical differential classification and treatment.Methods: Selecting 100 cases of this disease as study object(50 cases in blood stasis type group and 50 cases in damp-heat type group),and taking the healthy voluntary persons as the normal control group. We choose the 13 clinical index of the disease and apply statistics which include Rank sum test, Analysis of variance ，Logistic regression ect. to explore the relativity between familiar syndrome differention of TCM (including blood stasis type and damp-heat type )and