糖网煎剂治疗非增殖型糖尿病性视网膜病变的临床探究.pdfVIP

提 要 目的：评价“糖网煎剂”治疗非增殖型糖尿病性视网膜病变的临床疗效，探讨“糖网 煎剂”疏肝解郁、化瘀通络的作用机制。 方法：临床采集符合标准的非增殖型糖尿病性视网膜病变患者共 67 例，按随机对照 原则分为对照组和治疗组，对照组口服“羟苯磺酸钙胶囊”，治疗组口服“糖网煎剂”， 均治疗 12 个周。观察治疗前后的视力、眼底、眼底荧光造影、血管内皮生长因子及 内皮素的变化情况，客观评价治疗效果。 结果：①两组均能改善患者的中医症候，且治疗组有效率明显优于对照组；②两组均 能提高视力，但治疗组和对照组组间比较无统计学意义；③两组均能显著促进眼底出 血、渗出的吸收，改善眼底微循环，对糖尿病性视网膜病变的疗效显著，且治疗组优 于对照组；④两组均能抑制血管内皮生长因子的生成和降低内皮素水平，且治疗组优 于对照组。 结论：“糖网煎剂”具有改善临床症状、促进视力的恢复和改善眼底病变的作用，是 治疗非增殖型糖尿病性视网膜病变安全有效的方剂。 关键词 糖网煎剂；非增殖型糖尿病性视网膜病变；血管内皮生长因子；内皮素 Clinical Study on Curing Non-proliferative Diabetic Retinopathy with Tang Wang Jianji Speciality: Endocrinology of TCM Author: Yang na Tutor: Zhang dexian Abstract Objective : To evaluate the efficiency of Tang Wang Jianji for treatment of non-proliferative diabetic retinopathy (NPDR) and investigate the mechanism of Tang Wang Jianji for Shugan Jieyu and Huayu Tongluo. Methods: 67 patients with type 2 diabetes mellitus concurrent with non-proliferative diabetic retinopathy were clinically gathered and randomly divided into the treatment group treated with Tang Wang Jianji and the control group treated with Calcium Dobesilate Capsules. Curative effects were observed objectively. The sight 、fundus photography and fundus fluorescence angio- graphy were detected before and after 12 week′s treatment. Results: ①Two groups can improve traditional Chinese symptom, but the improvement of the treated group is significantly better than the control group; ②Two groups can improve sight, but the result were not significant between two groups; ③Two groups can absorb the blood and ooze of retina, improve the capillary circulation of retina, and the improvement the treated group is significantly better than the