肝病与内分泌疾病（Liver diseases and endocrine diseases）.docVIP

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肝病与内分泌疾病（Liver diseases and endocrine diseases）.doc

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肝病与内分泌疾病（Liver diseases and endocrine diseases）

肝病与内分泌疾病（Liver diseases and endocrine diseases） Some patients with primary hepatocellular carcinoma may have polycythemia and hypercholesterolemia, which may be due to erythropoietin and parathyroid hormone-like polypeptides. Shan the livers metabolic decline in hormones: many hormones, such as insulin, estrogen, and glucocorticoids, are mainly inactivated in the liver, and some hormones, such as corticosteroids and androgens, can degrade simultaneously in the liver and other tissues. Shan and plasma binding abnormalities: hormones in the circulation of most of the plasma protein with the loss of biological activity, liver dysfunction, plasma protein synthesis disorder, can indirectly affect the plasma total and free hormone concentrations. Shan liver on the site of hormone inactivation may be the same as hormones on the active site (receptor) of the liver, so when the liver injury, the decomposition of hormones, although decreased, but the role of hormones in the liver is also reduced. I. Liver disease and adrenocortical hormone Adrenocortical hormones are secreted by the adrenal cortex and almost all of them are inactivated in the liver, so there are metabolic abnormalities in the liver disease. Normal human corticosteroids were removed very quickly in plasma, while the plasma removal time of corticosteroids in patients with chronic liver disease was prolonged. The mechanism is due to: Shan Portal-Body shunt, so that the amount of cortical hormones in the liver is reduced, Shan in the liver to the corticosteroid-binding reaction of glucose and glyoxylic, reduction of the reaction and so on. The liver is converted to four hydrogen derivatives by reducing the 4, 3 ketone radicals on the cortical steroid a ring, which produces 17-ketone steroids. When the liver function is not complete, the main deficiency of corticosteroid metabolism is 4, 3 keto. As a result, the excretion of 17 of steroids and 17 of corticosteroids in urine decreased, and the half-life of corticos