舒乐冲剂治疗肝郁伤神型失眠症的临床探究.pdf

提 要 目的:观察以疏肝解郁兼以活血化痰为治则研制的舒乐冲剂对肝郁伤神型失眠症 患者的疗效并对其进行安全性评估。方法:将60例符合纳入标准的失眠症患者随机分 为治疗组30例和对照组30例。治疗组采用舒乐冲剂治疗，对照组口服舒眠胶囊，治 疗周期为 4 周，观察患者在中医证候、抑郁自评量表（SDS）及匹兹堡睡眠质量指数 （PSQI）积分等方面的改善情况及是否存在不良反应。结果:治疗组临床总有效率 80.00%，与对照组比较无显著性差异（P＞0.05）；中医证候疗效方面，治疗组总有效 率83.33%，与对照组比较无显著性差异（P＞0.05）；治疗后治疗组在中医证候积分、 匹兹堡睡眠质量指数（PSQI）积分方面均有明显改善，与对照组比较无显著性差异（P ＞0.05）；治疗组在抑郁自评量表（SDS）积分及胁肋胀痛、情绪低落、不思饮食症状 改善方面优于对照组（P＜0.05），且临床观察无明显不良反应。结论:舒乐冲剂对肝 郁伤神型失眠症有较好的临床疗效。 关键词 失眠症；肝郁伤神；疏肝解郁；舒乐冲剂 The Clinical Research of the Treatment of Insomnia of Vitality injured by stagnation of the liver-qi Type with ShuLe granule Speciality:Chinese Internal Medicine Author:Li Zhen Tutor:Li Chunhong Abstract Purpose: To observe the effect and safety evaluation of the ShuLe granule (made in the rules of relieving depression of the liver-qi ，promoting blood circulation and resolving phlegm) on treating Insomnia of Vitality injured by stagnation of the liver-qi Type. Method ：In the clinical study, randomized principles, sixty patients conforming to standard were divided into treatment group(30cases) and control group (30cases). The treatment group was treated by ShuLe granule, while the control group was treated by ShuMian capsule. Four weeks was a course of treatment. The scores of the TCM symptom, SDS and PSQI were observed before and after the treatment.We observed adverse reactions. Results: The total efficiency of the treatment group was 80.00%, and the treatment group’s was 83.33% in the TCM symptom. There were no significant clinical differences (P0.05) between these two groups. The improvement of the treatment group in scores of SDS ， flank pain and appetite depression was significantly better than control group (P 0.05 ). Also, it has no significant cli