补肾益髓方防治肿瘤化疗骨髓毒性的临床探究.pdfVIP

提 要 研究目的：通过对中医药防治化疗后骨髓抑制的中医治则研究，试以客观评价以 补肾为中心的中药方剂——补肾益髓方，防治化疗后骨髓抑制的有效性。初步揭示化 疗后骨髓抑制的证治基本规律。研究方法：选择60例晚期肺癌或乳腺癌患者，随机分 为观察组和对照组，其中观察组30例，对照组30例，两组均给予联合化疗DP方案（DP： 多西紫杉醇75 mg/㎡ ,d1静脉滴注；顺铂25-30mg/㎡，d1-d3静脉滴注，21天为一个 周期），观察组自化疗第一天起同时予补肾益髓方加减，日1剂,分早晚2次水煎服至 化疗第21天，对照组单纯使用化疗方案（如两组出现Ⅲ度以上骨髓抑制则中止试验， 予对症处理）。观察两组各疗程中第7天、第14天、第21天时的骨髓抑制情况。研究 结果：补肾益髓方对化疗后骨髓抑制具有一定的保护作用，它能在一定程度上减轻化 疗后外周血WBC、HGB、PLT下降的程度，降低骨髓抑制的发生率，明显加速抑制后骨 髓的恢复，从而保障化疗如期进行，提高患者生存质量，且未发生毒、副作用。研究 结论：本研究表明，以补肾益髓方作为非小细胞肺癌化疗的辅助治疗,可明显提高骨 髓正常细胞的增生能力,促进白细胞、血红蛋白、血小板生成,能预防化疗引起的血象 下降,而且临床应用未见明显毒副反应,在预防、治疗化疗引起的骨髓抑制具有较好效 果。 关键词 化疗 骨髓抑制 中医治疗 补肾论 Clinical Observation of the Effect the Kidney Tonify and Marrow Benefit Formula Alleviating Bone Marrow after the Chemotherapy to Tumor Speciality: Internal Medicine of Integrated TCM and Western Medicine Author: Meng Jing Tutor: Professor Qi Yuanfu Abstract Objective: through the prevention of TCM to bone marrow inhibit after chemotherapy medicine, evaluate objectively the effect of the Kidney Tonify and Marrow Benefit Formula which is formula of the center theory tonifying the kidney of TCM to prevent the bone marrow inhibit, and disclose preliminarily evidence to the basic rule of bone marrow inhibition after chemotherapy.Method: choose 60 later period patients with lung cancer or breast cancer , which were randomly separated into observation group and control group, among the observation group 30 cases and the control grounp 30 cases, both groups offerred a combination chemotherapy DP scheme (DP:Docetaxel,75 mg / ㎡, d1 intravenous drip; Cisplatin,30mg/㎡, d1-d3 intravenous drip, 21 days for a period).From the 1st day the observation group add the Kidney Tonify and Marrow Benefit Formula,1 agent and poi