解毒通络法防治PCI术后RS的临床及实验研究.pdfVIP

提 要 目的：从临床、实验两方面对 PCI 术后 RS 的病机和治疗方法进行深入的探讨， 以寻求新的研究思路和治疗方药。 方法：根据查阅文献和导师多年临床经验,提出PCI术后RS的病机主要为“毒瘀 互结”的假说，并拟定解毒通络方。临床观察治疗 PCI 术后患者 50 例，分为治疗组 和对照组作比较研究，两组均治疗1个月，随访6个月。实验观察该方药对体外培养 大鼠血管成纤维细胞的增殖、对ET-1及NO等细胞因子的调控来验证提出的假说。 结果：临床研究显示解毒通络治疗组较对照组能明显改善临床症状，降低心绞痛 的复发率，升高左室射血分数，降低 C 反应蛋白。实验研究显示解毒通络方能够抑 制血管成纤维细胞的增殖，同时降低 ET-1，升高 NO，改善血管成纤维细胞的代谢， 有利于预防PCI术后RS的发生。 结论：解毒通络方能够有效防治 PCI 术后 RS 的发生。深化了中医学对 PCI 术后 RS 的病机认识，对该病的治疗提出了新的研究思路和治疗方药。为丰富该病的治疗 学做了有益的探索和尝试。 关键词 解毒通络；PCI术后；再狭窄；临床研究；实验研究 The Clinical and Experimental Research of JieDuTongLuo to controll the RS after PCI Professional: Integrative Medicine in Science Author: Chi Liping Instructor Name: Li Yunlun Abstract Objective: Studying the pathogenes and treatment methods of RS after PCI from clinical and experimental aspects is to find new research ideas and treatment prescriptions. Methods: From the literature and teacher years of clinical experience, We propose the pathogenesis of RS after PCI is mainly toxic stasis each knot hypothesis and develop JieDuTongLuo side. 50 clinical patients after PCI are divided into treatment and control groups for comparative study, both groups are 1 month of treatment, followed up for 6 months; experiment is observed from the prescriptions of cultured rat vascular fibroblasts proliferation and some cytokines to verify the proposed hypothesis, such as NO and ET-1 . Results: The clinical study shows JieDuTongLuo treatment group can significantly improve the clinical symptoms and reduce the recurrence rate