解毒通络饮治疗椎—基底动脉供血不足性眩晕的临床探究.pdfVIP

提 要 目的：观察解毒通络法中药组方对椎-基底动脉供血不足性眩晕的疗效并初步探 讨其作用机理。 方法：60 例患者随机分为两组，治疗组 30 例，对照组 30 例。治疗组给予解毒 通络之中药煎剂和常规西药治疗，对照组给予阿司匹林肠溶片加辛伐他汀片和常规西 药治疗，观察治疗前后临床症状、体征和实验室检查指标的变化。 结果：经治疗 8 周后，治疗组总有效率为 96.67%,与对照组比较有显著性差异 （P0.05）。同时，总胆固醇 （TC）、甘油三酯 （TG）、白细胞（WBC）、红细胞压积 （HCT）、 纤维蛋白原（Fg）、血栓素 B (TXB)、内皮素（ET）明显降低（P0.05 或 P0.01）， 2 2 一氧化氮（NO）、6-酮一前列腺素Fla (6-keto-PGFIa )显著升高（P0.01）,其中HCT、 6-keto-PGFIa、ET与对照组比较有显著性差异（P0.05）。 结论：以解毒通络法组方的中药对椎-基底动脉供血不足性眩晕有较好的防治作 用。 关键词 椎-基底动脉供血不足；眩晕；解毒通络；热毒；络病 Clinical Study of Vertebrobasilar Insufficiency Vertigo Treated With Chinese Drugs of Detoxicating and Promoting Collaterals Speciality: Internal Medicine of TCM Author: Liu Wen Juan Tutor: prof. You Ke Abstract Objective: To study the curative effect of Vertebrobasilar Insufficiency Vertigo treated with the removing toxin and activating collaterals herbal medicines, and to discuss the mechanisms of this therapy. Methods: 60 cases were divided into 2 groups at random, 30 cases in treatment group and 30 cases in control group. The removing toxin and activating collaterals herbal medicines and routine Western medicine were administrated to the cases of treatment group. Aspirin Enteric-coated Tablets, Simvastatin Tablets and routine western medicine were administrated to the cases of control group. Changes of clinical syndromes , signs and lab indexes were detected before and after treatment. Results: 8 weeks later ,we found total effective rate of treatment group was 96.67%, compared with control group, there was predominant difference (P0.05). At the same time , we found this therapy can lower TC 、TG、LDL 、WBC 、HCT 、Fg 、TXB2 、ET, and impro