罗本燕_痴呆 - 浙江大学.ppt

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
罗本燕_痴呆 - 浙江大学

痴呆的诊断 工作能力或日常生活功能受到影响 比以往的功能和执行力水平有所下降 无法用谵妄或主要精神障碍解释 包括以下至少两个领域的认知或行为损害 学习并记住新信息的能力 推理能力和处理复杂任务的能力 视空间功能 语言功能 人格、行为或举动改变 * AD是慢性进行性的神经退行性病变,依患者疾病的严重程度,病程大致可分为三个阶段:轻度、中度、重度。在不同阶段,临床症状会逐渐加重。至终末期,患者丧失基本生活能力,终日卧床,大小便失禁。 Left) Structural healthy brain networks were obtained from diffusion MRI scans of 14 young healthy volunteers, followed by whole brain tractography. The nodes of this network correspond to cortical and subcortical gray matter regions obtained from a labeled T1-weighted brain atlas, and the edges of this network are proportional to the number and strength of the ?ber tracts that connect the nodes. Proposed network diffusion model and its eigenmodes are derived from this healthy network. The ?rst three eigenmodes, which we have hypothesized to be predictive of dementia atrophy patterns, are then tabulated and plotted. (Right) We then compare the predicted patterns with measured atrophy of dementia patients (AD, bvFTD, and age-matched normal subjects), obtained via a completely separate processing pipeline, available in the SPM Matlab toolbox. T1-weighted images of each subject were coregistered with the same atlas as in the left panel, and graymatter regions were parcellated using the prelabeled atlas information. Volume of each cortical and subcortical gray- matter region was measured. The atrophy of each region was obtained in terms of a t-statistic between the diseased and age-matched normal groups. Finally, the predicted and measured atrophy patterns were statistically compared using correlation analysis. * 这些标记物支持AD诊断,但鉴别AD与其他痴呆诊断时特异性低(39 – 90%),这可能与合并AD病理改变有关 目前尚缺乏统一的检测和样本处理方法 血管炎、感染或脱髓鞘疾病 * NMDA受体(N-methyl-D-aspartic acid receptor)即为N-甲基-D-天冬氨酸受体 * * * * β-secretase (also known as the β-site APP-cleaving enzyme;BACE1) initiates the amyloidogenic pathway because of aseptic meningoencephalitis in some patients, which was attributed to cytotoxic T cells and/or autoimmune reactions to AN-1972. CAD-106 is a vaccine th

文档评论(0)

wangyueyue + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档