细胞内bmal1和cbp蛋白水平的振荡表达被减弱.pptVIP

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease Molecular Neurodegeneration (19 March 2015；IF= 6.563；PMID 王宁 2015.10.8 IMI CONFIDENTIAL Background * Aβ, Amyloid-beta SCN, Suprachiasmatic nucleus CBP, Creb-binding protein Per2, Period circadian protein homolog 2 BMAL1, Aryl hydrocarbon receptor nuclear translocator-like 生理节律相关的蛋白，时钟基因： IMI CONFIDENTIAL Materials and Methods * Animal : 5XFAD mice (APP/PSEN1) AD小鼠 APP K670N/M671L+I716V+V717I PSEN1 M146L+L286V Cell: HT22 mouse hippocampal cells,