益肾助阳活血化浊方加味对多囊卵巢综合征患者卵巢多囊样改变的影响.pdf

2015 年6月第 22卷第6期 中国中医药信息杂志 ·35· 益肾助阳活血化浊方加味对多囊卵巢综合征患者 卵巢多囊样改变的影响 高征,指导：许昕 首都医科大学附属北京中医医院,北京 100010 摘要：目的 观察益肾助阳活血化浊方加味对多囊卵巢综合征 (PCOS)脾肾两虚痰湿证患者卵巢病理状态的 影响及其安全性。方法 将 123例患者采用计算机中央随机法分为观察组 64 例和对照组 59 例,观察组口服益 肾助阳活血化浊方加味,对照组口服复方醋酸环丙孕酮片,2 组均以 3 个月为 1 个疗程,连续治疗 2 个疗程。观 察 2 组患者治疗前后卵巢体积及卵泡数目变化,并评价其安全性。结果 观察组和对照组患者双侧卵巢体积均 较治疗前缩小 (P ＜0.05,P ＜0.01),对照组疗效更明显 (P ＜0.01)。2 组治疗后卵泡数目均有减少趋势,组间比 较差异无统计学意义 (P ＞0.05)。观察组不良反应率低于对照组。结论 益肾助阳活血化浊方加味治疗 PCOS 能使异常增大的卵巢体积缩小或复常,且不良反应少。 关键词：多囊卵巢综合征；益肾助阳活血化浊方加味；卵巢多囊样改变 DOI：10.3969/j.issn.1005-5304.2015.06.011 中图分类号：R271.917.51 文献标识码：A 文章编号：1005-5304(2015)06-0035-04 Effects of Modified Yishen Zhuyang Huoxue Huazhuo Formula on Changes of Polycystic Ovarian in Patients with Polycystic Ovarian Syndrome GAO Zheng, Instructor ：XU Xin (Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China) Abstract ：Objective To observe the effect and safety of modified Yishen Zhuyang Huoxue Huazhuo Formula for polycystic ovarian syndrome (PCOS) in the TCM pattern of deficiency of spleen and kidney with phlegm-dampness. Methods Totally 123 cases were recruited into this study and randomized to two groups by central random approach, 64 cases in the observation group and 59 cases in the control group. Patients in the observation group were given the modified Yishen Zhuyang Huoxue Huazhuo Formula, while those in the control group were given compound cyproterone acetate tablet, for two treatment courses, three months for one course. The changes of ovarian volume and the number of follicles before and after treatment were observed. Adverse reactions were also evaluated. Results Bilateral ovarian volumes in both groups