补肾化痰方联合盐酸多奈哌齐对中重度阿尔茨海默病伴精神行为症状 .pdfVIP

江医学2013 年第35 卷第23 期 补肾化痰方联合盐酸多奈哌齐 对中重度阿尔茨海默病伴精神 行为症状的临床研究 郭忠伟 陈杏丽 邢 平 张江涛 【摘要 】 目的 评价补肾化痰方联合盐酸多奈哌齐对中重度阿尔茨海默病（AD ）伴精神行为症状（BPSD ）的 效及安全性。 方法 127 例AD 患者按照随机数字表法分为研究组62 例和对照组65 例，研究组患者服用补肾化痰代表方复方海蛇胶囊和盐酸 多奈哌齐，对照组患者单用盐酸多奈哌齐；观察 12 周。治 前及治 12 周末分别采用痴呆行为量表（BEHAVE-AD ）评价精神行为症 状，严重障碍量表（SIB ）评定患者的认知功能。 结果 治 12 周末，研究组BEHAVE-AD 分值下降较对照组更显著（P 0.01 ）；研究 组治疗后SIB 评分与对照组的差异有统计学意义（P 0.01 ）；研究组改善BPSD 有效率明显高于对照组（P 0.01 ）。两组不良反应症状 均轻微，且发生率差异无统计学意义（P ＞0.05 ）。结论 补肾化痰代表方复方海蛇胶囊联合盐酸多奈哌齐治 BPSD 的 效优于单 用盐酸多奈哌齐。 【关键词】 复方海蛇胶囊 盐酸多奈哌齐 阿尔茨海默病 精神行为症状 Clinical study of reinhartdt and sea cucumber capsule combined with donepezil in treatment of psychological and behavioral symptoms in patients with Alzheimers disease China 【Abstract 】 Objective To study the efficacy and safety of Reinhartdt and sea cucumber capsule (RSC) combined with donepezil on behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimers Disease. Methods One hundred and sixty seven patients were randomized into combined group and Donepezil group, and both groups were treated re- spectively for 12 weeks. The curative effect was evaluated according to SIB and BEHAVE-AD score. Results Compared with the baseline, BEHAVE-AD scores decreased significantly both in the two groups after 12 weeks of treatment (both P 0.00 1), but the improvement in the combined treatment group was more obvious than that in Donepezil group (P0.01). Among the two groups, SIB score increased significantly only in the combined treatment group (P0.001). No obvious adverse reaction occurred in the two groups. Conclusion RSC combined with Donepezil is more effective in treatment of BPSD than single Donepezil. 【Key words 】 Reinhartdt and sea cucumber capsule Donepezil Alzheimers disease Psychological and behavioral symptoms