哌罗匹隆与奋乃静对精神分裂症患者认知功能和社会功能的 - 中国药房.pdfVIP

哌罗匹隆与奋乃静对精神分裂症患者认知功能和社会功能的影 响比较 ＊ # 孙 磊 ，陈清刚（天津市安定医院，天津 300222） 中图分类号 R749.3 文献标志码 A 文章编号 1001-0408（2015）12-1619-03 DOI 10.6039/j.issn.1001-0408.2015.12.13 摘 要 目的：比较哌罗匹隆与奋乃静对精神分裂症患者认知功能和社会功能的影响。方法：将94例精神分裂症患者随机均分 为哌罗匹隆组和奋乃静组。两组患者治疗前均停用抗精神病药物2周。哌罗匹隆组患者给予哌罗匹隆片，初始剂量8mg ，2周后 剂量增加至12～48mg ，口服，每日3次；奋乃静组患者给予奋乃静片，初始剂量6mg ，2周后剂量增加至20～40mg ，口服，每日3 次。两组患者疗程均为8周。观察两组患者治疗前后认知功能评分，个人与社会功能量表（PSP ）总评分及不良反应发生情况。 结果：治疗前两组患者认知功能评分、PSP 总评分比较，差异均无统计学意义（P ＞0.05）。治疗后两组患者认知功能评分均显著低 于同组治疗前，差异均有统计学意义（P ＜0.01）；但两组间比较除言语记忆、视觉记忆、迷宫外（P ＞0.05），其他指标哌罗匹隆组均 低于奋乃静组，差异有统计学意义（P ＜0.01）。治疗后两组患者PSP 总评分显著高于同组治疗前，且哌罗匹隆组高于奋乃静组，差 异有统计学意义（P ＜0.01）。哌罗匹隆组患者不良反应发生率显著低于奋乃静组，差异有统计学意义（P ＜0.01）。结论：哌罗匹隆 在改善精神分裂症患者的认知功能、社会功能及安全性方面均优于奋乃静。 关键词 精神分裂症；哌罗匹隆；奋乃静；认知功能；社会功能 Comparison of the Effects of Perospirone and Perphenazine on Cognitive Function and Social Function of Schizophrenic Patients SUN Lei ，CHEN Qing-gang（Tianjin Anding Hospital ，Tianjin 300222，China ） ABSTRACT OBJECTIVE ：To compare the effects of perospirone and perphenazine on cognitive function and social function of schizophrenic patients. METHODS ：A total of 94 schizophrenic patients were randomly divided into perospirone group and perphen- azine group. All patients were stopped antipsychotics drugs for 2 weeks before treatment. Patients in perospirone group were first orally given perospirone tablets 8 mg ，then 12-48 mg after 2 weeks ，3times a day. Patients in perphenazine group were first orally given perphenazine tasblets 6mg ，then 20-40mg after 2weeks ，3times a day. The course of both was 8weeks. There was no com- bination of other antipsychotics drugs during the treatment. The data was observed ，including cognitive function score （CFS ），per- sonal and social functioning scale （PSP ）and adverse reaction （ADR ）incidence. RESULTS ：There were no significant differences between the C