twist activation by hypoxia-inducible factor-1 综合评论透.pdf

中華癌醫會誌 (J. Chinese Oncol. Soc.) 25(5), 317-325, 2009 journal homepage:.tw/web/index.asp Review Article Deep into the Cancer Metastasis and Development: TWIST Activation by Hypoxia-Inducible Factor-1 Yao-Yu Hsieh, Muh-Hwa Yang* Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Abstract. During the development and progression of cancer, hypoxia acts as an important factor. In the low oxygen environment, hypoxia-inducible factor-1 (HIF-1) stabilizes and mediates the hypoxic response through activating the transcription of hypoxia-inducible genes that regulate variable cellular functions including metabolism, invasion, angiogenesis, and epithelial-mes- enchymal transition (EMT), a major process of metastasis. TWIST, an important regulator of gastrulation and mesoderm specification, also acts as a cornerstone in cancer metastasis. We recently showed the relationship between HIF-1 and TWIST. In hypoxic status, cancer cells ini- tiate a complicated network that augments the EMT through regulation of different EMT in- ducers by HIF-1. TWIST activation by hypoxia, a phenomenon constantly observed in embry- onic development, may suggest the role of HIF-1α/TWIST/Snail co-expression as a prognostic marker in cancer patients as well as a therapeutic target in treatment or prevention of metastasis. Keywords : epithelial-mesenchymal transition, HIF-1α, metastasis, TWIST 綜合評論 透視腫瘤轉移及生長的關鍵：缺氧誘導因子-1 活化 TWIST 蛋白 謝燿宇 楊慕華* 台北榮民總醫院 內科部血液腫瘤科 TAO 中文摘要 在腫瘤生長與惡化的過程中，缺氧扮演很重要的角色。