呼吸道合胞病毒非结构蛋白ns1、ns2的研究进展.pdfVIP

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 2011 5 NS1N S2 卜选运 ( , 650224) : 呼吸道合胞病毒( resp iratory syncytialvirus, RSV)是引起婴幼儿和老年人下呼吸道感染的重要病原体之一由 该病毒的致病机理还不太清楚导致目前尚无有效治疗 RSV 的方法研究表明, 呼吸道合胞病毒的非结构蛋白 NS1NS2具 有抗细胞凋亡的作用, 同时可以逃避宿主免疫系统( IFN ) 对病毒的干扰,有利 病毒复制敲除这两种基因的减毒活疫苗和 表达沉默 NS1的小干扰 RNA ( siRNA )的质粒研究已经取得了一定的进展对非结构蛋白功能的深入研究有助 了解 RSV的 致病机理, 同时为预防和治疗 RSV 感染奠定理论基础 : 呼吸道合胞病毒 NS1 NS2 IFN 减毒活疫苗 siRSV NS1 R esearch D evelopm ent of RSV N onstructural P roteins N S1 and N S2 Bu Xuanyun (College of Lif e Sciences, Kunm ing University of Science and Technology, K unm ing 650224) Abstract: Human respiratory syncytialvirus (RSV ) is one of the most mi portant pathogen of serious resp iratory tract illness in infants and ch ildren aswell as old people. The w ay of how to lead to d isease is still notvery clear now, so thatw e still dont know how to therapy the RSV infection. The research proved that RSV nonstructural proteins NS1 and NS2 suppress prem ature apoptosis and es cape from the IFN to protect to benefit for the replication of virus. The RSV vaccine ofwh ich is attenuated by deleted NS gene and the p lasm ids encod ing sm all interfering RNAs forNS1 is deep ly researched. The research of nonstructural proteinsw ill help us to do deeper research of the w ay how does RSV lead to d isease, w ill give us basis of the prophylaxis and therapy against RSV infection of hum ans. K ey w ords: Resp iratory syncytial virus NS1 NS2 IFN L ive attenuated vaccine siRSV NS1 ( respiratory syncytial virus, NS, RSV RSV), , RSV , NS RSV , , , RNA, 120 300 nm, 15 222 bp, 1 N S 10, 11, 3 NS1N