recent advance in the study on prevention and - 临床与病理杂志.pdfVIP

国际病理科学与临床杂志 2013, 33(6) Int J Path ol Clin Me d 525 DOI:10.3969/j.issn.1673-2588.2013.06.015 /gjblkx/fileup/PDF/201306525.pdf 葡萄中白藜芦醇对肿瘤防治作用的研究进展 刘远锦，林亲录，罗非君 综述 (中南林业科技大学食品科学与工程学院食品营养与健康研究室，长沙 410004) [摘　要] 白藜芦醇是一种大量存在于葡萄中的多酚化合物，具有抗肿瘤、抗心血管疾病和调节免疫等作 用。文章总结了白藜芦醇对不同类型肿瘤细胞的抑制作用，阐述了其主要通过抑制癌细胞的增 殖、促进细胞凋亡、降低肿瘤细胞的侵袭能力和增强放射治疗敏感性等途径抗癌，并从分子水平 阐明其作用的分子靶点及分子机制，最后对白藜芦醇的抗癌机制和其对健康、医疗、经济的贡献 作了展望。 [关键词] 白藜芦醇；凋亡；增殖；多酚化合物；抗肿瘤 Recent advance in the study on prevention and treatment for cancer by resveratrol in grape LIU Yuanjin, LIN Qinlu, LUO Feijun (Laboratory of Food Nutrient and Health, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China) Abstract Resveratrol is a polyphenol compound, at high level in grapes in particular. Resveratrol can exert the effects of antitumor, anti-cardiovascular disease regulation of immunity, etc. This article summarized the antitumor effect , and the molecular targets of resveratrol and the underlying mechanisms, including inhibition of proliferation, promotion of apoptosis, decrease of invasion ability and enhancement of radiotherapy sensitivity for tumor cells. Furthermore, we provided an outlook regarding the beneficial effects of resveratrol on human health, medical care, and economy. Key words resveratrol; apoptosis; proliferation; polyphenol compound; antitumor 白藜芦醇是一种存在于葡萄科、蓼科等植物 葡 萄 皮 和 葡 萄 籽 中